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MicroRNAs and pro-inflammatory cytokines as candidate biomarkers for recent-onset psychosis

BACKGROUND: Recent studies on the schizophrenia spectrum and other psychotic disorders showed that alternation of immune system components, particularly microRNAs (miRNAs) and pro-inflammatory compounds, plays a significant role in developing the illness. The study aimed to evaluate serum expression...

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Autores principales: Shafiee-Kandjani, Ali Reza, Nezhadettehad, Negin, Farhang, Sara, Bruggeman, Richard, Shanebandi, Dariush, Hassanzadeh, Mohammadbagher, Azizi, Hosein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463450/
https://www.ncbi.nlm.nih.gov/pubmed/37644489
http://dx.doi.org/10.1186/s12888-023-05136-6
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author Shafiee-Kandjani, Ali Reza
Nezhadettehad, Negin
Farhang, Sara
Bruggeman, Richard
Shanebandi, Dariush
Hassanzadeh, Mohammadbagher
Azizi, Hosein
author_facet Shafiee-Kandjani, Ali Reza
Nezhadettehad, Negin
Farhang, Sara
Bruggeman, Richard
Shanebandi, Dariush
Hassanzadeh, Mohammadbagher
Azizi, Hosein
author_sort Shafiee-Kandjani, Ali Reza
collection PubMed
description BACKGROUND: Recent studies on the schizophrenia spectrum and other psychotic disorders showed that alternation of immune system components, particularly microRNAs (miRNAs) and pro-inflammatory compounds, plays a significant role in developing the illness. The study aimed to evaluate serum expression of the miRNA-26a, miRNA-106a, and miRNA-125b as genetic factors and serum levels of IL-6, IL-1β, and TNF-α as pro-inflammatory factors in an IranianAzeri population. METHODS: Forty patients with recent-onset non-affective psychosis and 40 healthy people as a control group were involved. Expression levels of miRNAs and serum levels of the cytokines were measured using RT-qPCR and ELISA, respectively. T-test, receiver operating characteristics (ROC), and spearman correlation coefficient were carried out data analysis. RESULTS: Findings showed higher levels of IL-6, IL-1β, TNF-α, miR-26a, and miR-106a in the plasma of the patients’ group compared with the control. miRNA-26a showed a statistically significant higher level (p < .003) compared to the control group, with AUC = 0.84 (95% CI: 0.77 to 0.93, P < .001) and cut-off point = 0.17 in comparison to other miRNAs as mentioned above; in this regard, it might be a suggestive biomarker for schizophrenia in the early stage of the illness. Moreover, miRNAs’ expression level was not substantially associated with the level of any measured cytokines above. CONCLUSIONS: miR-26a might be a suggestive biomarker for schizophrenia in the early stage of the illness. Given that the relationship between other miRNAs and cytokines is not yet well understood; accordingly, there are encouragement and support for continued research in this fascinating field.
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spelling pubmed-104634502023-08-30 MicroRNAs and pro-inflammatory cytokines as candidate biomarkers for recent-onset psychosis Shafiee-Kandjani, Ali Reza Nezhadettehad, Negin Farhang, Sara Bruggeman, Richard Shanebandi, Dariush Hassanzadeh, Mohammadbagher Azizi, Hosein BMC Psychiatry Research BACKGROUND: Recent studies on the schizophrenia spectrum and other psychotic disorders showed that alternation of immune system components, particularly microRNAs (miRNAs) and pro-inflammatory compounds, plays a significant role in developing the illness. The study aimed to evaluate serum expression of the miRNA-26a, miRNA-106a, and miRNA-125b as genetic factors and serum levels of IL-6, IL-1β, and TNF-α as pro-inflammatory factors in an IranianAzeri population. METHODS: Forty patients with recent-onset non-affective psychosis and 40 healthy people as a control group were involved. Expression levels of miRNAs and serum levels of the cytokines were measured using RT-qPCR and ELISA, respectively. T-test, receiver operating characteristics (ROC), and spearman correlation coefficient were carried out data analysis. RESULTS: Findings showed higher levels of IL-6, IL-1β, TNF-α, miR-26a, and miR-106a in the plasma of the patients’ group compared with the control. miRNA-26a showed a statistically significant higher level (p < .003) compared to the control group, with AUC = 0.84 (95% CI: 0.77 to 0.93, P < .001) and cut-off point = 0.17 in comparison to other miRNAs as mentioned above; in this regard, it might be a suggestive biomarker for schizophrenia in the early stage of the illness. Moreover, miRNAs’ expression level was not substantially associated with the level of any measured cytokines above. CONCLUSIONS: miR-26a might be a suggestive biomarker for schizophrenia in the early stage of the illness. Given that the relationship between other miRNAs and cytokines is not yet well understood; accordingly, there are encouragement and support for continued research in this fascinating field. BioMed Central 2023-08-29 /pmc/articles/PMC10463450/ /pubmed/37644489 http://dx.doi.org/10.1186/s12888-023-05136-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Shafiee-Kandjani, Ali Reza
Nezhadettehad, Negin
Farhang, Sara
Bruggeman, Richard
Shanebandi, Dariush
Hassanzadeh, Mohammadbagher
Azizi, Hosein
MicroRNAs and pro-inflammatory cytokines as candidate biomarkers for recent-onset psychosis
title MicroRNAs and pro-inflammatory cytokines as candidate biomarkers for recent-onset psychosis
title_full MicroRNAs and pro-inflammatory cytokines as candidate biomarkers for recent-onset psychosis
title_fullStr MicroRNAs and pro-inflammatory cytokines as candidate biomarkers for recent-onset psychosis
title_full_unstemmed MicroRNAs and pro-inflammatory cytokines as candidate biomarkers for recent-onset psychosis
title_short MicroRNAs and pro-inflammatory cytokines as candidate biomarkers for recent-onset psychosis
title_sort micrornas and pro-inflammatory cytokines as candidate biomarkers for recent-onset psychosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463450/
https://www.ncbi.nlm.nih.gov/pubmed/37644489
http://dx.doi.org/10.1186/s12888-023-05136-6
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