Jatrophone: a cytotoxic macrocylic diterpene targeting PI3K/AKT/NF-κB pathway, inducing apoptosis and autophagy in resistant breast cancer cells

BACKGROUND: Breast cancer is a prevalent malignant tumor that affects women worldwide. The primary challenge in treating breast cancer is combating drug resistance, which contributes to relapse and metastasis. Jatrophone is a unique macrocyclic jatrophane diterpene found in various Jatropha and Euph...

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Detalles Bibliográficos
Autores principales: Shari, Khawlah, El Gedaily, Rania A., Allam, Rasha M., Meselhy, Khaled M., Khaleel, Amal E., Abdel-Sattar, Essam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463460/
https://www.ncbi.nlm.nih.gov/pubmed/37608270
http://dx.doi.org/10.1186/s12906-023-04113-6

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