Improving the cytotoxicity of immunotoxins by reducing the affinity of the antibody in acidic pH

BACKGROUND: Immunotoxins are antibody-toxin conjugates that bind to surface antigens and exert effective cytotoxic activity after internalization into tumor cells. Immunotoxins exhibit effective cytotoxicity and have been approved by the FDA to treat multiple hematological malignancies, such as hair...

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Detalles Bibliográficos
Autores principales: Liu, Xiaoyu, Tan, Qingqing, Wen, Jiaqi, Wang, Xufei, Yang, Gang, Li, Yuxiao, Lu, Ming, Ye, Wei, Si, Anfeng, Ma, Sujuan, Ding, Tong, Sun, Luan, Liu, Fang, Zhang, Mei, Jiang, Tao, Gao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463491/
https://www.ncbi.nlm.nih.gov/pubmed/37626430
http://dx.doi.org/10.1186/s12967-023-04210-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463491/
https://www.ncbi.nlm.nih.gov/pubmed/37626430
http://dx.doi.org/10.1186/s12967-023-04210-7

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