Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate

BACKGROUND: Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 (GPX3) was one of the differentially expressed genes in BPH identified by transcriptome sequencing of 5 hyperplastic and...

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Detalles Bibliográficos
Autores principales: Li, Yan, Zhou, Yongying, Liu, Daoquan, Wang, Zhen, Qiu, Jizhang, Zhang, Junchao, Chen, Ping, Zeng, Guang, Guo, Yuming, Wang, Xinghuan, DiSanto, Michael E., Zhang, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463608/
https://www.ncbi.nlm.nih.gov/pubmed/37633909
http://dx.doi.org/10.1186/s12967-023-04432-9

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