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Intrinsic disorder in PRAME and its role in uveal melanoma

INTRODUCTION: The PReferentially expressed Antigen in MElanoma (PRAME) protein has been shown to be an independent biomarker for increased risk of metastasis in Class 1 uveal melanomas (UM). Intrinsically disordered proteins and regions of proteins (IDPs/IDPRs) are proteins that do not have a well-d...

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Detalles Bibliográficos
Autores principales: Antonietti, Michael, Gonzalez, David J. Taylor, Djulbegovic, Mak, Dayhoff, Guy W., Uversky, Vladimir N., Shields, Carol L., Karp, Carol L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463658/
https://www.ncbi.nlm.nih.gov/pubmed/37626310
http://dx.doi.org/10.1186/s12964-023-01197-y