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MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value

Treatment with the alkylating agent temozolomide is known to be prognostically beneficial in a subset of glioblastoma patients. Response to such chemotherapeutic treatment and the prognostic benefit have been linked to the methylation status of O(6)-methylguanine-DNA methyltransferase (MGMT). To dat...

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Detalles Bibliográficos
Autores principales:	Leske, Henning, Camenisch Gross, Ulrike, Hofer, Silvia, Neidert, Marian Christoph, Leske, Sabine, Weller, Michael, Lehnick, Dirk, Rushing, Elisabeth Jane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463744/ https://www.ncbi.nlm.nih.gov/pubmed/37641156 http://dx.doi.org/10.1186/s40478-023-01622-w

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