Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity

G(4)C(2) hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). G(4)C(2) insertion length is variable, and patients can carry up to several thousand repeats. Dipeptide re...

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Detalles Bibliográficos
Autores principales: Morón-Oset, Javier, Fischer, Lilly Katharina Sophie, Jauré, Nathalie, Zhang, Pingze, Jahn, Annika Julia, Supèr, Tessa, Pahl, André, Isaacs, Adrian M., Grönke, Sebastian, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463776/
https://www.ncbi.nlm.nih.gov/pubmed/37644512
http://dx.doi.org/10.1186/s40478-023-01634-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463776/
https://www.ncbi.nlm.nih.gov/pubmed/37644512
http://dx.doi.org/10.1186/s40478-023-01634-6

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