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Clinical features and surgical selection in colitis-associated colorectal cancer with ulcerative colitis

PURPOSE: The aim of this study was to compare the clinical characteristics of ulcerative colitis (UC) patients who underwent surgery for cancer/dysplasia with those who underwent surgery for refractory disease and to discuss the preoperative preparation for successful hand-sewn IPAA. METHODS: Patien...

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Autores principales: Kuwahara, Ryuichi, Ikeuchi, Hiroki, Kusunoki, Kurando, Minagawa, Tomohiro, Horio, Yuki, Kimura, Kei, Kataoka, Kozo, Beppu, Naohito, Ikeda, Masataka, Uchino, Motoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463818/
https://www.ncbi.nlm.nih.gov/pubmed/37641118
http://dx.doi.org/10.1186/s12893-023-02160-x
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author Kuwahara, Ryuichi
Ikeuchi, Hiroki
Kusunoki, Kurando
Minagawa, Tomohiro
Horio, Yuki
Kimura, Kei
Kataoka, Kozo
Beppu, Naohito
Ikeda, Masataka
Uchino, Motoi
author_facet Kuwahara, Ryuichi
Ikeuchi, Hiroki
Kusunoki, Kurando
Minagawa, Tomohiro
Horio, Yuki
Kimura, Kei
Kataoka, Kozo
Beppu, Naohito
Ikeda, Masataka
Uchino, Motoi
author_sort Kuwahara, Ryuichi
collection PubMed
description PURPOSE: The aim of this study was to compare the clinical characteristics of ulcerative colitis (UC) patients who underwent surgery for cancer/dysplasia with those who underwent surgery for refractory disease and to discuss the preoperative preparation for successful hand-sewn IPAA. METHODS: Patients who underwent surgery for UC between January 2014 and December 2021 at Hyogo Medical University were included in the study. A total of 443 UC surgical cases were included in the study, which comprised 188 cancer/dysplasia patients and 255 refractory patients. Clinical records were compared retrospectively. RESULTS: The proportion of surgical UC cases with cancer/dysplasia has been on the rise, accounting for approximately 40% in recent years. The duration of disease (months) was 186 (2–590) in the cancer/dysplasia group and 48 (1–580) in the refractory group (p = 0.02). UC severity (mild/moderate/severe) was 119/69/0 in the cancer/dysplasia group and 18/157/80 in the refractory group (p < 0.01). The four nutrition factors of weight (55.2 (32.7–99.6) kg: 49.9 (20.3–85.2) kg), body mass index (21.0 (13.9–32.5) kg/m2: 18.3 (11.4–34.1)kg/m2), serum albumin level (4.3 (2.7–5.0)g/dl: 3.4 (1.4–5.2)g/dl) and prognostic nutrition index (49.2 (33.2–61.2): 40.9 (17.4–61.1)) were significantly higher in the cancer/dysplasia group (p < 0.01). The degree of obesity was also significantly higher in the cancer/dysplasia group (p < 0.01). CONCLUSION: UC patients with cancer/dysplasia were more likely than refractory patients to have mild inflammation; they also had a longer duration of UC disease and better nutritional status.
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spelling pubmed-104638182023-08-30 Clinical features and surgical selection in colitis-associated colorectal cancer with ulcerative colitis Kuwahara, Ryuichi Ikeuchi, Hiroki Kusunoki, Kurando Minagawa, Tomohiro Horio, Yuki Kimura, Kei Kataoka, Kozo Beppu, Naohito Ikeda, Masataka Uchino, Motoi BMC Surg Research PURPOSE: The aim of this study was to compare the clinical characteristics of ulcerative colitis (UC) patients who underwent surgery for cancer/dysplasia with those who underwent surgery for refractory disease and to discuss the preoperative preparation for successful hand-sewn IPAA. METHODS: Patients who underwent surgery for UC between January 2014 and December 2021 at Hyogo Medical University were included in the study. A total of 443 UC surgical cases were included in the study, which comprised 188 cancer/dysplasia patients and 255 refractory patients. Clinical records were compared retrospectively. RESULTS: The proportion of surgical UC cases with cancer/dysplasia has been on the rise, accounting for approximately 40% in recent years. The duration of disease (months) was 186 (2–590) in the cancer/dysplasia group and 48 (1–580) in the refractory group (p = 0.02). UC severity (mild/moderate/severe) was 119/69/0 in the cancer/dysplasia group and 18/157/80 in the refractory group (p < 0.01). The four nutrition factors of weight (55.2 (32.7–99.6) kg: 49.9 (20.3–85.2) kg), body mass index (21.0 (13.9–32.5) kg/m2: 18.3 (11.4–34.1)kg/m2), serum albumin level (4.3 (2.7–5.0)g/dl: 3.4 (1.4–5.2)g/dl) and prognostic nutrition index (49.2 (33.2–61.2): 40.9 (17.4–61.1)) were significantly higher in the cancer/dysplasia group (p < 0.01). The degree of obesity was also significantly higher in the cancer/dysplasia group (p < 0.01). CONCLUSION: UC patients with cancer/dysplasia were more likely than refractory patients to have mild inflammation; they also had a longer duration of UC disease and better nutritional status. BioMed Central 2023-08-28 /pmc/articles/PMC10463818/ /pubmed/37641118 http://dx.doi.org/10.1186/s12893-023-02160-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Kuwahara, Ryuichi
Ikeuchi, Hiroki
Kusunoki, Kurando
Minagawa, Tomohiro
Horio, Yuki
Kimura, Kei
Kataoka, Kozo
Beppu, Naohito
Ikeda, Masataka
Uchino, Motoi
Clinical features and surgical selection in colitis-associated colorectal cancer with ulcerative colitis
title Clinical features and surgical selection in colitis-associated colorectal cancer with ulcerative colitis
title_full Clinical features and surgical selection in colitis-associated colorectal cancer with ulcerative colitis
title_fullStr Clinical features and surgical selection in colitis-associated colorectal cancer with ulcerative colitis
title_full_unstemmed Clinical features and surgical selection in colitis-associated colorectal cancer with ulcerative colitis
title_short Clinical features and surgical selection in colitis-associated colorectal cancer with ulcerative colitis
title_sort clinical features and surgical selection in colitis-associated colorectal cancer with ulcerative colitis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463818/
https://www.ncbi.nlm.nih.gov/pubmed/37641118
http://dx.doi.org/10.1186/s12893-023-02160-x
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