EspE3 plays a role in the pathogenicity of avian pathogenic Escherichia coli

APEC encodes multiple virulence factors that have complex pathogenic mechanisms. In this study, we report a virulence factor named EspE3, which can be secreted from APEC. This protein was predicted to have a leucine-rich repeat domain (LRR) and may have a similar function to IpaH class effectors of ...

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Autores principales: Li, Qianwen, Qi, Zhao, Fu, Dandan, Tang, Bo, Song, Xiangjun, Shao, Ying, Tu, Jian, Qi, Kezong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463865/
https://www.ncbi.nlm.nih.gov/pubmed/37644523
http://dx.doi.org/10.1186/s13567-023-01202-9
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author Li, Qianwen
Qi, Zhao
Fu, Dandan
Tang, Bo
Song, Xiangjun
Shao, Ying
Tu, Jian
Qi, Kezong
author_facet Li, Qianwen
Qi, Zhao
Fu, Dandan
Tang, Bo
Song, Xiangjun
Shao, Ying
Tu, Jian
Qi, Kezong
author_sort Li, Qianwen
collection PubMed
description APEC encodes multiple virulence factors that have complex pathogenic mechanisms. In this study, we report a virulence factor named EspE3, which can be secreted from APEC. This protein was predicted to have a leucine-rich repeat domain (LRR) and may have a similar function to IpaH class effectors of the type III secretion system (T3SS). For further exploration, the regulatory correlation between the espE3 and ETT2 genes in APEC was analysed. We then assessed the pathogenicity of EspE3, detected it in APEC secretion proteins and screened the proteins of EspE3 that interact with chicken trachea epithelial cells. This study provides data on a new virulence factor for further exploring the pathogenic mechanism of APEC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13567-023-01202-9.
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spelling pubmed-104638652023-08-30 EspE3 plays a role in the pathogenicity of avian pathogenic Escherichia coli Li, Qianwen Qi, Zhao Fu, Dandan Tang, Bo Song, Xiangjun Shao, Ying Tu, Jian Qi, Kezong Vet Res Research Article APEC encodes multiple virulence factors that have complex pathogenic mechanisms. In this study, we report a virulence factor named EspE3, which can be secreted from APEC. This protein was predicted to have a leucine-rich repeat domain (LRR) and may have a similar function to IpaH class effectors of the type III secretion system (T3SS). For further exploration, the regulatory correlation between the espE3 and ETT2 genes in APEC was analysed. We then assessed the pathogenicity of EspE3, detected it in APEC secretion proteins and screened the proteins of EspE3 that interact with chicken trachea epithelial cells. This study provides data on a new virulence factor for further exploring the pathogenic mechanism of APEC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13567-023-01202-9. BioMed Central 2023-08-29 2023 /pmc/articles/PMC10463865/ /pubmed/37644523 http://dx.doi.org/10.1186/s13567-023-01202-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Li, Qianwen
Qi, Zhao
Fu, Dandan
Tang, Bo
Song, Xiangjun
Shao, Ying
Tu, Jian
Qi, Kezong
EspE3 plays a role in the pathogenicity of avian pathogenic Escherichia coli
title EspE3 plays a role in the pathogenicity of avian pathogenic Escherichia coli
title_full EspE3 plays a role in the pathogenicity of avian pathogenic Escherichia coli
title_fullStr EspE3 plays a role in the pathogenicity of avian pathogenic Escherichia coli
title_full_unstemmed EspE3 plays a role in the pathogenicity of avian pathogenic Escherichia coli
title_short EspE3 plays a role in the pathogenicity of avian pathogenic Escherichia coli
title_sort espe3 plays a role in the pathogenicity of avian pathogenic escherichia coli
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463865/
https://www.ncbi.nlm.nih.gov/pubmed/37644523
http://dx.doi.org/10.1186/s13567-023-01202-9
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