Discovery biomarker to optimize obeticholic acid treatment for non-alcoholic fatty liver disease

The response rate to obeticholic acid (OCA), a potential therapeutic agent for non-alcoholic fatty liver disease, is limited. This study demonstrated that upregulation of the alternative bile acid synthesis pathway increases the OCA treatment response rate. The hepatic transcriptome and bile acid me...

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Detalles Bibliográficos
Autores principales: Lee, Seung Min, Jun, Dae Won, Yoon, Eileen Laurel, Oh, Ju Hee, Roh, Yoon Jin, Lee, Eun Jeoung, Shin, Ji-Hee, Nam, Young-Do, Kim, Hyun Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463927/
https://www.ncbi.nlm.nih.gov/pubmed/37626369
http://dx.doi.org/10.1186/s13062-023-00407-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463927/
https://www.ncbi.nlm.nih.gov/pubmed/37626369
http://dx.doi.org/10.1186/s13062-023-00407-4

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