Rapid and accurate genotyping of human SNP rs671 in aldehyde dehydrogenase 2 gene using one-step CRISPR/Cas12b assay without DNA amplification

BACKGROUND: The SNP rs671 of Human aldehyde dehydrogenase (ALDH) is G-A transition at 1510th nucleotides, which is an important clinical indicator of alcoholic liver disease, digestive tract cancer and some drug efficiency. The commonly used genotyping assay of this polymorphism is relatively time-c...

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Detalles Bibliográficos
Autores principales: Wu, Fang, Xue, Yong, Wang, Yan, Si, Xinxin, Zhang, Xinyue, Xu, Yuyang, Luo, Zhidan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464061/
https://www.ncbi.nlm.nih.gov/pubmed/37641062
http://dx.doi.org/10.1186/s13008-023-00095-6

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