Targeted delivery of a PD-1-blocking scFv by CD133-specific CAR-T cells using nonviral Sleeping Beauty transposition shows enhanced antitumour efficacy for advanced hepatocellular carcinoma

BACKGROUND: CD133 is considered a marker for cancer stem cells (CSCs) in several types of tumours, including hepatocellular carcinoma (HCC). Chimeric antigen receptor-specific T (CAR-T) cells targeting CD133-positive CSCs have emerged as a tool for the clinical treatment of HCC, but immunogenicity,...

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Detalles Bibliográficos
Autores principales: Yang, Chaopin, You, Jinqi, Pan, Qiuzhong, Tang, Yan, Cai, Liming, Huang, Yue, Gu, Jiamei, Wang, Yizhi, Yang, Xinyi, Du, Yufei, Ouyang, Dijun, Chen, Hao, Zhong, Haoran, Li, Yongqiang, Yang, Jieying, Han, Yulong, Sun, Fengze, Chen, Yuanyuan, Wang, Qijing, Weng, Desheng, Liu, Zhongqiu, Xiang, Tong, Xia, Jianchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464109/
https://www.ncbi.nlm.nih.gov/pubmed/37635247
http://dx.doi.org/10.1186/s12916-023-03016-0

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