Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal

BACKGROUND: Hundreds of functional genomic screens have been performed across a diverse set of cancer contexts, as part of efforts such as the Cancer Dependency Map, to identify gene dependencies—genes whose loss of function reduces cell viability or fitness. Recently, large-scale screening efforts...

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Detalles Bibliográficos
Autores principales: Krill-Burger, J. Michael, Dempster, Joshua M., Borah, Ashir A., Paolella, Brenton R., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C., McFarland, James M., Vazquez, Francisca, Tsherniak, Aviad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464129/
https://www.ncbi.nlm.nih.gov/pubmed/37612728
http://dx.doi.org/10.1186/s13059-023-03020-w

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