m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway

BACKGROUND: Gemcitabine resistance has brought great challenges to the treatment of pancreatic cancer. The N6-methyladenosine (m6A) mutation has been shown to have a significant regulatory role in chemosensitivity; however, it is not apparent whether gemcitabine resistance can be regulated by fat ma...

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Detalles Bibliográficos
Autores principales: Lin, Kai, Zhou, Endi, Shi, Ting, Zhang, Siqing, Zhang, Jinfan, Zheng, Ziruo, Pan, Yuetian, Gao, Wentao, Yu, Yabin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464189/
https://www.ncbi.nlm.nih.gov/pubmed/37605223
http://dx.doi.org/10.1186/s13046-023-02792-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464189/
https://www.ncbi.nlm.nih.gov/pubmed/37605223
http://dx.doi.org/10.1186/s13046-023-02792-0

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