Cargando…

m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway

BACKGROUND: Gemcitabine resistance has brought great challenges to the treatment of pancreatic cancer. The N6-methyladenosine (m6A) mutation has been shown to have a significant regulatory role in chemosensitivity; however, it is not apparent whether gemcitabine resistance can be regulated by fat ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Kai, Zhou, Endi, Shi, Ting, Zhang, Siqing, Zhang, Jinfan, Zheng, Ziruo, Pan, Yuetian, Gao, Wentao, Yu, Yabin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464189/ https://www.ncbi.nlm.nih.gov/pubmed/37605223 http://dx.doi.org/10.1186/s13046-023-02792-0

Ejemplares similares

The m(6)A eraser FTO facilitates proliferation and migration of human cervical cancer cells
por: Zou, Dongling, et al.
Publicado: (2019)

Correction to: The m(6)A eraser FTO facilitates proliferation and migration of human cervical cancer cells
por: Zou, Dongling, et al.
Publicado: (2020)

Gene Polymorphisms of m6A Erasers FTO and ALKBH1 Associated with Susceptibility to Gastric Cancer
por: Li, Yue, et al.
Publicado: (2022)

NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma
por: Huang, Zhi-Jun, et al.
Publicado: (2017)

FTO fuels diabetes-induced vascular endothelial dysfunction associated with inflammation by erasing m(6)A methylation of TNIP1
por: Zhou, Chuandi, et al.
Publicado: (2023)

CFDP1 promotes hepatocellular carcinoma progression through activating NEDD4/PTEN/PI3K/AKT signaling pathway
por: Zhou, Yan, et al.
Publicado: (2022)

m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis
por: Yang, Youjing, et al.
Publicado: (2023)

PTEN and NEDD4 in Human Breast Carcinoma
por: Chen, Yilun, et al.
Publicado: (2015)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

Erase que erase -- : cuentos
por: Massieu, Cuca
Publicado: (1982)

Pan-Cancer Analysis of the N6-Methyladenosine Eraser FTO as a Potential Prognostic and Immunological Biomarker
por: Zhao, Chengwen, et al.
Publicado: (2021)

Role of m6A writers, erasers and readers in cancer
por: Fang, Zhen, et al.
Publicado: (2022)

The detection and functions of RNA modification m(6)A based on m(6)A writers and erasers
por: Zhang, Wei, et al.
Publicado: (2021)

PTEN modulates neurites outgrowth and neuron apoptosis involving the PI3K/Akt/mTOR signaling pathway
por: Liu, Shen, et al.
Publicado: (2019)

Notoginsenoside R7 suppresses cervical cancer via PI3K/PTEN/Akt/mTOR signaling
por: Li, Li, et al.
Publicado: (2017)

Ontogenic mRNA expression of RNA modification writers, erasers, and readers in mouse liver
por: Chen, Liming, et al.
Publicado: (2019)

SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway
por: Liu, Jia, et al.
Publicado: (2014)

circACTR2 attenuates gemcitabine chemoresiatance in pancreatic cancer through PTEN mediated PI3K/AKT signaling pathway
por: Xu, Chao, et al.
Publicado: (2023)

YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA
por: Zhang, Zhaolong, et al.
Publicado: (2020)

Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade
por: Tseng, Hsin-Wei, et al.
Publicado: (2022)

Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells
por: Wang, Jian, et al.
Publicado: (2021)

Substrates of the m(6)A demethylase FTO: FTO-LINE1 RNA axis regulates chromatin state in mESCs
por: Sommerkamp, Pia
Publicado: (2022)

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention
por: Davis, Nicole M., et al.
Publicado: (2014)

E3 Ligase Nedd4 Promotes Axon Branching by Downregulating PTEN
por: Drinjakovic, Jovana, et al.
Publicado: (2010)

Human Schlafen 5 Inhibits Proliferation and Promotes Apoptosis in Lung Adenocarcinoma via the PTEN/PI3K/AKT/mTOR Pathway
por: Gu, Xuefeng, et al.
Publicado: (2021)

Prognostic and Predictive Value of m6A “Eraser” Related Gene Signature in Gastric Cancer
por: Xu, Xin, et al.
Publicado: (2021)

YAP manipulates proliferation via PTEN/AKT/mTOR-mediated autophagy in lung adenocarcinomas
por: Xu, Wei, et al.
Publicado: (2021)

Deregulation of N6-Methyladenosine RNA Modification and Its Erasers FTO/ALKBH5 among the Main Renal Cell Tumor Subtypes
por: Guimarães-Teixeira, Catarina, et al.
Publicado: (2021)

Discovery of novel mRNA demethylase FTO inhibitors against esophageal cancer
por: Qin, Bo, et al.
Publicado: (2022)

Mutations in the HECT domain of NEDD4L lead to AKT/mTOR pathway deregulation and cause periventricular nodular heterotopia
por: Broix, Loïc, et al.
Publicado: (2016)

The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging
por: Jiang, Zhong-xin, et al.
Publicado: (2021)

FTO promotes liver inflammation by suppressing m6A mRNA methylation of IL-17RA
por: Gan, Xiaojie, et al.
Publicado: (2022)

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
por: Chappell, William H., et al.
Publicado: (2011)

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response
por: McCubrey, James A., et al.
Publicado: (2012)

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer
por: Ellis, Leigh, et al.
Publicado: (2013)

PI3K/Akt/mTOR signaling & its regulator tumour suppressor genes PTEN & LKB1 in human uterine leiomyomas
por: Makker, Annu, et al.
Publicado: (2016)

Overexpression of PTEN may increase the effect of pemetrexed on A549 cells via inhibition of the PI3K/AKT/mTOR pathway and carbohydrate metabolism
por: Li, Bo, et al.
Publicado: (2019)

The m6A(m)-independent role of FTO in regulating WNT signaling pathways
por: Kim, Hyunjoon, et al.
Publicado: (2022)

Genome-Wide Identification, Expression and Evolution Analysis of m6A Writers, Readers and Erasers in Aegilops_tauschii
por: Lin, Huiyuan, et al.
Publicado: (2023)

Erasing Institutional Bias
por: Jana, Tiffany
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ghmum5lofsj579jjdj64r8c10q