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Discovery of novel JAK1 inhibitors through combining machine learning, structure-based pharmacophore modeling and bio-evaluation

BACKGROUND: Janus kinase 1 (JAK1) plays a critical role in most cytokine-mediated inflammatory, autoimmune responses and various cancers via the JAK/STAT signaling pathway. Inhibition of JAK1 is therefore an attractive therapeutic strategy for several diseases. Recently, high-performance machine lea...

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Detalles Bibliográficos
Autores principales:	Wang, Zixiao, Sun, Lili, Xu, Yu, Liang, Peida, Xu, Kaiyan, Huang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464202/ https://www.ncbi.nlm.nih.gov/pubmed/37641144 http://dx.doi.org/10.1186/s12967-023-04443-6

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