Refined read‐out: The hUHRF1 Tandem‐Tudor domain prefers binding to histone H3 tails containing K4me1 in the context of H3K9me2/3

UHRF1 is an essential chromatin protein required for DNA methylation maintenance, mammalian development, and gene regulation. We investigated the Tandem‐Tudor domain (TTD) of human UHRF1 that is known to bind H3K9me2/3 histones and is a major driver of UHRF1 localization in cells. We verified bindin...

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Detalles Bibliográficos
Autores principales: Choudalakis, Michel, Kungulovski, Goran, Mauser, Rebekka, Bashtrykov, Pavel, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464304/
https://www.ncbi.nlm.nih.gov/pubmed/37593997
http://dx.doi.org/10.1002/pro.4760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464304/
https://www.ncbi.nlm.nih.gov/pubmed/37593997
http://dx.doi.org/10.1002/pro.4760

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