Amantadine for NeuroenhaNcement in acutE patients Study - a protocol for a prospective pilot proof of concept phase IIb study in intensive and intermediate care unit patients (ANNES)

BACKGROUND: Persisting coma is a common complication in (neuro)intensive care in neurological disease such as acute ischemic stroke, intracerebral hemorrhage or subarachnoid hemorrhage. Amantadine acts as a nicotinic receptor antagonist, dopamine receptor agonist and non-competitive N-Methyl-D-aspar...

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Detalles Bibliográficos
Autores principales: Hofmann, Anna, Blum, Corinna, Single, Constanze, Adeyemi, Kamal, Schwarz, Patricia, Siokas, Vasileios, Rattay, Tim W., Häberle, Helene A., Riessen, Reimer, Brendel, Bettina, Haug, Iris, Bösel, Ruth, Zago, Manola, Martus, Peter, Ziemann, Ulf, Mengel, Annerose, Feil, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464325/
https://www.ncbi.nlm.nih.gov/pubmed/37608315
http://dx.doi.org/10.1186/s12883-023-03345-w

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