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CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer

BACKGROUND: Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation of colorectal cancer (CRC). However, whether this epigenetic mechanism is functional in cancer or is a mere consequence of the carcinogenic process remains to be elucidated. RE...

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Detalles Bibliográficos
Autores principales:	Tejedor, Juan Ramón, Peñarroya, Alfonso, Gancedo-Verdejo, Javier, Santamarina-Ojeda, Pablo, Pérez, Raúl F., López-Tamargo, Sara, Díez-Borge, Ana, Alba-Linares, Juan J., González-del-Rey, Nerea, Urdinguio, Rocío G., Mangas, Cristina, Roberti, Annalisa, López, Virginia, Morales-Ruiz, Teresa, Ariza, Rafael R., Roldán-Arjona, Teresa, Meijón, Mónica, Valledor, Luis, Cañal, María Jesús, Fernández-Martínez, Daniel, Fernández-Hevia, María, Jiménez-Fonseca, Paula, García-Flórez, Luis J., Fernández, Agustín F., Fraga, Mario F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464368/ https://www.ncbi.nlm.nih.gov/pubmed/37612734 http://dx.doi.org/10.1186/s13148-023-01546-1

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