Neuroprotective effect of nose-to-brain delivery of Asiatic acid in solid lipid nanoparticles and its mechanisms against memory dysfunction induced by Amyloid Beta(1-42) in mice

BACKGROUND: Amyloid-β(1-42) (Aβ(1-42)) plays an essential role in the development of the early stage of Alzheimer’s disease (AD). Asiatic acid (AA), an active compound in Centella asiatica L, exhibit neuroprotective properties in previous studies. Due to its low bioavailability, the nose-to-brain de...

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Detalles Bibliográficos
Autores principales: Islamie, Ridho, Myint, Su Lwin Lwin, Rojanaratha, Tissana, Ritthidej, Garnpimol, Wanakhachornkrai, Oraphan, Wattanathamsan, Onsurang, Rodsiri, Ratchanee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464452/
https://www.ncbi.nlm.nih.gov/pubmed/37608290
http://dx.doi.org/10.1186/s12906-023-04125-2

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