Cargando…

Circulating PCSK9 as a prognostic biomarker of cardiovascular events in individuals with type 2 diabetes: evidence from a 16.8-year follow-up study

BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality, being twofold to fourfold more common in patients with type 2 diabetes mellitus (T2DM) than in individuals without diabetes. However, despite this decade-old knowledge, the identification of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruscica, Massimiliano, Macchi, Chiara, Giuliani, Angelica, Rizzuto, Alessandra Stefania, Ramini, Deborah, Sbriscia, Matilde, Carugo, Stefano, Bonfigli, Anna Rita, Corsini, Alberto, Olivieri, Fabiola, Sabbatinelli, Jacopo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464486/ https://www.ncbi.nlm.nih.gov/pubmed/37620933 http://dx.doi.org/10.1186/s12933-023-01948-8

Ejemplares similares

Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study
por: Sabbatinelli, Jacopo, et al.
Publicado: (2022)

Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes
por: Sabbatinelli, Jacopo, et al.
Publicado: (2022)

PCSK9 Inhibition and Risk of Diabetes: Should We Worry?
por: Carugo, Stefano, et al.
Publicado: (2022)

Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation
por: Giuliani, Angelica, et al.
Publicado: (2023)

The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents
por: Giuliani, Angelica, et al.
Publicado: (2022)

Prognostic value of soluble ST2, high-sensitivity cardiac troponin, and NT-proBNP in type 2 diabetes: a 15-year retrospective study
por: Sabbatinelli, Jacopo, et al.
Publicado: (2022)

Effect of Sphingomyelinase-Treated LDLs on HUVECs
por: Giuliani, Angelica, et al.
Publicado: (2023)

Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes
por: Bonafè, Massimiliano, et al.
Publicado: (2020)

Lipoprotein(a) and PCSK9 inhibition: clinical evidence
por: Ruscica, Massimiliano, et al.
Publicado: (2020)

Hypocholesterolaemic treatment in coronary unit: from statins to anti PCSK9 therapies and bempedoic acid
por: Ferri, Nicola, et al.
Publicado: (2023)

Response to: Letter to the Editor on “Bonafè M, Prattichizzo F, Giuliani A, Storci G, Sabbatinelli J, Olivieri F. Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes. Cytokine Growth Factor Rev” by Eugenia Quiros-Roldan, Giorgio Biasiotto and Isabella Zanella
por: Prattichizzo, Francesco, et al.
Publicado: (2021)

Proteomics and Lipidomics to unveil the contribution of PCSK9 beyond cholesterol lowering: a narrative review
por: Gianazza, Erica, et al.
Publicado: (2023)

Long-term exposure of human endothelial cells to metformin modulates miRNAs and isomiRs
por: Giuliani, Angelica, et al.
Publicado: (2020)

Impact of Soy β-Conglycinin Peptides on PCSK9 Protein Expression in HepG2 Cells
por: Macchi, Chiara, et al.
Publicado: (2021)

Extracellular vesicles circulating in young organisms promote healthy longevity
por: Prattichizzo, Francesco, et al.
Publicado: (2019)

A Data-Mining Approach to Identify NF-kB-Responsive microRNAs in Tissues Involved in Inflammatory Processes: Potential Relevance in Age-Related Diseases
por: Micolucci, Luigina, et al.
Publicado: (2023)

Replicative Senescence-Associated LINE1 Methylation and LINE1-Alu Expression Levels in Human Endothelial Cells
por: Ramini, Deborah, et al.
Publicado: (2022)

Genome-Wide Methylation Changes Associated with Replicative Senescence and Differentiation in Endothelial and Bone Marrow Mesenchymal Stromal Cells
por: Giuliani, Angelica, et al.
Publicado: (2023)

PCSK9 Confers Inflammatory Properties to Extracellular Vesicles Released by Vascular Smooth Muscle Cells
por: Greco, Maria Francesca, et al.
Publicado: (2022)

PCSK9 induces a pro-inflammatory response in macrophages
por: Ricci, Chiara, et al.
Publicado: (2018)

Role of lipoprotein(a) in plaque progression
por: Ruscica, Massimiliano, et al.
Publicado: (2022)

Association of admission serum levels of neurofilament light chain and in-hospital mortality in geriatric patients with COVID-19
por: Marchegiani, Francesca, et al.
Publicado: (2022)

Where Metabolism Meets Senescence: Focus on Endothelial Cells
por: Sabbatinelli, Jacopo, et al.
Publicado: (2019)

Circulating Inflamma-miRs as Potential Biomarkers of Cognitive Impairment in Patients Affected by Alzheimer’s Disease
por: Giuliani, Angelica, et al.
Publicado: (2021)

Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia
por: Protic, Olga, et al.
Publicado: (2022)

PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation
por: Dozio, Elena, et al.
Publicado: (2020)

Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial
por: Sabbatinelli, Jacopo, et al.
Publicado: (2020)

Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices
por: Perugini, Jessica, et al.
Publicado: (2022)

Circulating miR-320b and miR-483-5p levels are associated with COVID-19 in-hospital mortality()
por: Giuliani, Angelica, et al.
Publicado: (2022)

Associations Among PCSK9 Levels, Atherosclerosis-Derived Extracellular Vesicles, and Their miRNA Content in Adults With Obesity
por: Macchi, Chiara, et al.
Publicado: (2022)

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging
por: Conte, Maria, et al.
Publicado: (2020)

Naturally Occurring PCSK9 Inhibitors
por: Adorni, Maria Pia, et al.
Publicado: (2020)

Relationship between Circulating PCSK9 and Markers of Subclinical Atherosclerosis—The IMPROVE Study
por: Coggi, Daniela, et al.
Publicado: (2021)

Extracellular vesicle-shuttled miRNAs: a critical appraisal of their potential as nano-diagnostics and nano-therapeutics in type 2 diabetes mellitus and its cardiovascular complications
por: Prattichizzo, Francesco, et al.
Publicado: (2021)

PCSK9 Induces Rat Smooth Muscle Cell Proliferation and Counteracts the Pleiotropic Effects of Simvastatin
por: Lupo, Maria Giovanna, et al.
Publicado: (2021)

Bempedoic Acid: for Whom and When
por: Ruscica, Massimiliano, et al.
Publicado: (2022)

Depression and cardiovascular risk—association among Beck Depression Inventory, PCSK9 levels and insulin resistance
por: Macchi, C., et al.
Publicado: (2020)

Curcumin, Polydatin and Quercetin Synergistic Activity Protects from High-Glucose-Induced Inflammation and Oxidative Stress
por: Matacchione, Giulia, et al.
Publicado: (2022)

The mitomiR/Bcl-2 axis affects mitochondrial function and autophagic vacuole formation in senescent endothelial cells
por: Giuliani, Angelica, et al.
Publicado: (2018)

Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells
por: Giordani, Chiara, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dncjdurfvt2m42mqe49qlr743t