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Oral Isotretinoin and Its Uses in Dermatology: A Review
In 1982, the Food and Drug Administration (FDA) of the United States of America approved isotretinoin (13-cis-retinoic acid), a retinoid derivative of vitamin A, to treat severe recalcitrant acne vulgaris. Apart from its prescribed use for severe acne, evidence suggests that isotretinoin is commonly...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464604/ https://www.ncbi.nlm.nih.gov/pubmed/37649956 http://dx.doi.org/10.2147/DDDT.S427530 |
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author | Paichitrojjana, Anon Paichitrojjana, Anand |
author_facet | Paichitrojjana, Anon Paichitrojjana, Anand |
author_sort | Paichitrojjana, Anon |
collection | PubMed |
description | In 1982, the Food and Drug Administration (FDA) of the United States of America approved isotretinoin (13-cis-retinoic acid), a retinoid derivative of vitamin A, to treat severe recalcitrant acne vulgaris. Apart from its prescribed use for severe acne, evidence suggests that isotretinoin is commonly used off-label to treat mild-to-moderate acne, inflammatory skin conditions, genodermatoses, skin cancer, and other skin disorders. This is due to its anti-inflammatory, immunomodulatory, and antineoplastic properties. Some “off-label” use is successful, while others are ineffective. Therefore, this information is essential to clinicians for deciding on the appropriate use of isotretinoin. In this article, we aim to review the most updated evidence-based data about the use of oral isotretinoin in dermatology. |
format | Online Article Text |
id | pubmed-10464604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-104646042023-08-30 Oral Isotretinoin and Its Uses in Dermatology: A Review Paichitrojjana, Anon Paichitrojjana, Anand Drug Des Devel Ther Review In 1982, the Food and Drug Administration (FDA) of the United States of America approved isotretinoin (13-cis-retinoic acid), a retinoid derivative of vitamin A, to treat severe recalcitrant acne vulgaris. Apart from its prescribed use for severe acne, evidence suggests that isotretinoin is commonly used off-label to treat mild-to-moderate acne, inflammatory skin conditions, genodermatoses, skin cancer, and other skin disorders. This is due to its anti-inflammatory, immunomodulatory, and antineoplastic properties. Some “off-label” use is successful, while others are ineffective. Therefore, this information is essential to clinicians for deciding on the appropriate use of isotretinoin. In this article, we aim to review the most updated evidence-based data about the use of oral isotretinoin in dermatology. Dove 2023-08-25 /pmc/articles/PMC10464604/ /pubmed/37649956 http://dx.doi.org/10.2147/DDDT.S427530 Text en © 2023 Paichitrojjana and Paichitrojjana. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Paichitrojjana, Anon Paichitrojjana, Anand Oral Isotretinoin and Its Uses in Dermatology: A Review |
title | Oral Isotretinoin and Its Uses in Dermatology: A Review |
title_full | Oral Isotretinoin and Its Uses in Dermatology: A Review |
title_fullStr | Oral Isotretinoin and Its Uses in Dermatology: A Review |
title_full_unstemmed | Oral Isotretinoin and Its Uses in Dermatology: A Review |
title_short | Oral Isotretinoin and Its Uses in Dermatology: A Review |
title_sort | oral isotretinoin and its uses in dermatology: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464604/ https://www.ncbi.nlm.nih.gov/pubmed/37649956 http://dx.doi.org/10.2147/DDDT.S427530 |
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