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Oral Isotretinoin and Its Uses in Dermatology: A Review

In 1982, the Food and Drug Administration (FDA) of the United States of America approved isotretinoin (13-cis-retinoic acid), a retinoid derivative of vitamin A, to treat severe recalcitrant acne vulgaris. Apart from its prescribed use for severe acne, evidence suggests that isotretinoin is commonly...

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Autores principales: Paichitrojjana, Anon, Paichitrojjana, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464604/
https://www.ncbi.nlm.nih.gov/pubmed/37649956
http://dx.doi.org/10.2147/DDDT.S427530
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author Paichitrojjana, Anon
Paichitrojjana, Anand
author_facet Paichitrojjana, Anon
Paichitrojjana, Anand
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description In 1982, the Food and Drug Administration (FDA) of the United States of America approved isotretinoin (13-cis-retinoic acid), a retinoid derivative of vitamin A, to treat severe recalcitrant acne vulgaris. Apart from its prescribed use for severe acne, evidence suggests that isotretinoin is commonly used off-label to treat mild-to-moderate acne, inflammatory skin conditions, genodermatoses, skin cancer, and other skin disorders. This is due to its anti-inflammatory, immunomodulatory, and antineoplastic properties. Some “off-label” use is successful, while others are ineffective. Therefore, this information is essential to clinicians for deciding on the appropriate use of isotretinoin. In this article, we aim to review the most updated evidence-based data about the use of oral isotretinoin in dermatology.
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spelling pubmed-104646042023-08-30 Oral Isotretinoin and Its Uses in Dermatology: A Review Paichitrojjana, Anon Paichitrojjana, Anand Drug Des Devel Ther Review In 1982, the Food and Drug Administration (FDA) of the United States of America approved isotretinoin (13-cis-retinoic acid), a retinoid derivative of vitamin A, to treat severe recalcitrant acne vulgaris. Apart from its prescribed use for severe acne, evidence suggests that isotretinoin is commonly used off-label to treat mild-to-moderate acne, inflammatory skin conditions, genodermatoses, skin cancer, and other skin disorders. This is due to its anti-inflammatory, immunomodulatory, and antineoplastic properties. Some “off-label” use is successful, while others are ineffective. Therefore, this information is essential to clinicians for deciding on the appropriate use of isotretinoin. In this article, we aim to review the most updated evidence-based data about the use of oral isotretinoin in dermatology. Dove 2023-08-25 /pmc/articles/PMC10464604/ /pubmed/37649956 http://dx.doi.org/10.2147/DDDT.S427530 Text en © 2023 Paichitrojjana and Paichitrojjana. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Paichitrojjana, Anon
Paichitrojjana, Anand
Oral Isotretinoin and Its Uses in Dermatology: A Review
title Oral Isotretinoin and Its Uses in Dermatology: A Review
title_full Oral Isotretinoin and Its Uses in Dermatology: A Review
title_fullStr Oral Isotretinoin and Its Uses in Dermatology: A Review
title_full_unstemmed Oral Isotretinoin and Its Uses in Dermatology: A Review
title_short Oral Isotretinoin and Its Uses in Dermatology: A Review
title_sort oral isotretinoin and its uses in dermatology: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464604/
https://www.ncbi.nlm.nih.gov/pubmed/37649956
http://dx.doi.org/10.2147/DDDT.S427530
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