Cargando…
ANALYTICALLY CONFIRMED PRESENCE OF PSYCHOACTIVE SUBSTANCES, ESPECIALLY NEW PSYCHOACTIVE SUBSTANCES IN A GROUP OF PATIENTS HOSPITALIZED WITH MENTAL AND BEHAVIOURAL DISORDERS DUE TO THE USE OF PSYCHOACTIVE SUBSTANCES DIAGNOSIS
OBJECTIVES: The study assessed the presence of new psychoactive substances (NPS) in comparison to “classic” drugs in the group of newly admitted patients with mental and behavioral disorders due to the use of psychoactive substances diagnosis (section F11–19 according to ICD-10). MATERIAL AND METHOD...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nofer Institute of Occupational Medicine
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464757/ https://www.ncbi.nlm.nih.gov/pubmed/35543545 http://dx.doi.org/10.13075/ijomeh.1896.01863 |
_version_ | 1785098536866545664 |
---|---|
author | Engelgardt, Piotr Krzyżanowski, Maciej Piotrowski, Przemysław Borkowska-Sztachańska, Małgorzata Wasilewska, Agnieszka |
author_facet | Engelgardt, Piotr Krzyżanowski, Maciej Piotrowski, Przemysław Borkowska-Sztachańska, Małgorzata Wasilewska, Agnieszka |
author_sort | Engelgardt, Piotr |
collection | PubMed |
description | OBJECTIVES: The study assessed the presence of new psychoactive substances (NPS) in comparison to “classic” drugs in the group of newly admitted patients with mental and behavioral disorders due to the use of psychoactive substances diagnosis (section F11–19 according to ICD-10). MATERIAL AND METHODS: Data from anamnesis and the blood and urine samples were collected from 116 patients diagnosed with mental and behavioral disorders due to psychoactive substance use. All of them expressed written informed consent. Analytical confirmation was obtained by highperformance liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS). Liquid-liquid extraction was used for sample preparation. RESULTS: In the sample, 108 (93%) of 116 were positive for psychoactive substances (including 96 cases where >1 substance was found), 69% of individuals were tested positive for opioids and 67% for benzodiazepines. Eleven (9%) of 116 patient samples were positive for NPS. We detected 7 different substances. Six of them were synthetic cannabinoids: PB-22, MDMB-CHMICA, MMB-CHMICA, AB-CHMINACA, MMB-FUBINACA, THJ-2201 and one synthetic cathinone 3-CMC. CONCLUSIONS: The prevalence and NPS profile (the predominance of synthetic cannabinoids) are similar in the group of people with addiction to psychoactive substances as in populations of people taking recreational drugs and the overdose patients admitted to the hospital. |
format | Online Article Text |
id | pubmed-10464757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nofer Institute of Occupational Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-104647572023-08-29 ANALYTICALLY CONFIRMED PRESENCE OF PSYCHOACTIVE SUBSTANCES, ESPECIALLY NEW PSYCHOACTIVE SUBSTANCES IN A GROUP OF PATIENTS HOSPITALIZED WITH MENTAL AND BEHAVIOURAL DISORDERS DUE TO THE USE OF PSYCHOACTIVE SUBSTANCES DIAGNOSIS Engelgardt, Piotr Krzyżanowski, Maciej Piotrowski, Przemysław Borkowska-Sztachańska, Małgorzata Wasilewska, Agnieszka Int J Occup Med Environ Health Original Paper OBJECTIVES: The study assessed the presence of new psychoactive substances (NPS) in comparison to “classic” drugs in the group of newly admitted patients with mental and behavioral disorders due to the use of psychoactive substances diagnosis (section F11–19 according to ICD-10). MATERIAL AND METHODS: Data from anamnesis and the blood and urine samples were collected from 116 patients diagnosed with mental and behavioral disorders due to psychoactive substance use. All of them expressed written informed consent. Analytical confirmation was obtained by highperformance liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS). Liquid-liquid extraction was used for sample preparation. RESULTS: In the sample, 108 (93%) of 116 were positive for psychoactive substances (including 96 cases where >1 substance was found), 69% of individuals were tested positive for opioids and 67% for benzodiazepines. Eleven (9%) of 116 patient samples were positive for NPS. We detected 7 different substances. Six of them were synthetic cannabinoids: PB-22, MDMB-CHMICA, MMB-CHMICA, AB-CHMINACA, MMB-FUBINACA, THJ-2201 and one synthetic cathinone 3-CMC. CONCLUSIONS: The prevalence and NPS profile (the predominance of synthetic cannabinoids) are similar in the group of people with addiction to psychoactive substances as in populations of people taking recreational drugs and the overdose patients admitted to the hospital. Nofer Institute of Occupational Medicine 2022 2022-07-01 /pmc/articles/PMC10464757/ /pubmed/35543545 http://dx.doi.org/10.13075/ijomeh.1896.01863 Text en © 2006-2022 Journal hosting platform by Bentus https://creativecommons.org/licenses/by-nc/3.0/pl/This work is available in Open Access model and licensed under a Creative Commons Attribution-NonCommercial 3.0 Poland License – http://creativecommons.org/licenses/by-nc/3.0/pl/deed.en (https://creativecommons.org/licenses/by-nc/3.0/pl/) . |
spellingShingle | Original Paper Engelgardt, Piotr Krzyżanowski, Maciej Piotrowski, Przemysław Borkowska-Sztachańska, Małgorzata Wasilewska, Agnieszka ANALYTICALLY CONFIRMED PRESENCE OF PSYCHOACTIVE SUBSTANCES, ESPECIALLY NEW PSYCHOACTIVE SUBSTANCES IN A GROUP OF PATIENTS HOSPITALIZED WITH MENTAL AND BEHAVIOURAL DISORDERS DUE TO THE USE OF PSYCHOACTIVE SUBSTANCES DIAGNOSIS |
title | ANALYTICALLY CONFIRMED PRESENCE OF PSYCHOACTIVE SUBSTANCES, ESPECIALLY NEW PSYCHOACTIVE SUBSTANCES IN A GROUP OF PATIENTS HOSPITALIZED WITH MENTAL AND BEHAVIOURAL DISORDERS DUE TO THE USE OF PSYCHOACTIVE SUBSTANCES DIAGNOSIS |
title_full | ANALYTICALLY CONFIRMED PRESENCE OF PSYCHOACTIVE SUBSTANCES, ESPECIALLY NEW PSYCHOACTIVE SUBSTANCES IN A GROUP OF PATIENTS HOSPITALIZED WITH MENTAL AND BEHAVIOURAL DISORDERS DUE TO THE USE OF PSYCHOACTIVE SUBSTANCES DIAGNOSIS |
title_fullStr | ANALYTICALLY CONFIRMED PRESENCE OF PSYCHOACTIVE SUBSTANCES, ESPECIALLY NEW PSYCHOACTIVE SUBSTANCES IN A GROUP OF PATIENTS HOSPITALIZED WITH MENTAL AND BEHAVIOURAL DISORDERS DUE TO THE USE OF PSYCHOACTIVE SUBSTANCES DIAGNOSIS |
title_full_unstemmed | ANALYTICALLY CONFIRMED PRESENCE OF PSYCHOACTIVE SUBSTANCES, ESPECIALLY NEW PSYCHOACTIVE SUBSTANCES IN A GROUP OF PATIENTS HOSPITALIZED WITH MENTAL AND BEHAVIOURAL DISORDERS DUE TO THE USE OF PSYCHOACTIVE SUBSTANCES DIAGNOSIS |
title_short | ANALYTICALLY CONFIRMED PRESENCE OF PSYCHOACTIVE SUBSTANCES, ESPECIALLY NEW PSYCHOACTIVE SUBSTANCES IN A GROUP OF PATIENTS HOSPITALIZED WITH MENTAL AND BEHAVIOURAL DISORDERS DUE TO THE USE OF PSYCHOACTIVE SUBSTANCES DIAGNOSIS |
title_sort | analytically confirmed presence of psychoactive substances, especially new psychoactive substances in a group of patients hospitalized with mental and behavioural disorders due to the use of psychoactive substances diagnosis |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464757/ https://www.ncbi.nlm.nih.gov/pubmed/35543545 http://dx.doi.org/10.13075/ijomeh.1896.01863 |
work_keys_str_mv | AT engelgardtpiotr analyticallyconfirmedpresenceofpsychoactivesubstancesespeciallynewpsychoactivesubstancesinagroupofpatientshospitalizedwithmentalandbehaviouraldisordersduetotheuseofpsychoactivesubstancesdiagnosis AT krzyzanowskimaciej analyticallyconfirmedpresenceofpsychoactivesubstancesespeciallynewpsychoactivesubstancesinagroupofpatientshospitalizedwithmentalandbehaviouraldisordersduetotheuseofpsychoactivesubstancesdiagnosis AT piotrowskiprzemysław analyticallyconfirmedpresenceofpsychoactivesubstancesespeciallynewpsychoactivesubstancesinagroupofpatientshospitalizedwithmentalandbehaviouraldisordersduetotheuseofpsychoactivesubstancesdiagnosis AT borkowskasztachanskamałgorzata analyticallyconfirmedpresenceofpsychoactivesubstancesespeciallynewpsychoactivesubstancesinagroupofpatientshospitalizedwithmentalandbehaviouraldisordersduetotheuseofpsychoactivesubstancesdiagnosis AT wasilewskaagnieszka analyticallyconfirmedpresenceofpsychoactivesubstancesespeciallynewpsychoactivesubstancesinagroupofpatientshospitalizedwithmentalandbehaviouraldisordersduetotheuseofpsychoactivesubstancesdiagnosis |