Cargando…
Three year outcomes of intravitreal ranibizumab and aflibercept treatment of patients with diabetic macular edema: A comparative study
BACKGROUND: Diabetic macular edema (DME) is the most common cause of visual deterioration in patients with diabetes mellitus. Various treatment options have been used for DME, including intravitreal injection of steroids and anti-vascular endothelial growth factors. OBJECTIVES: To evaluate and compa...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464826/ https://www.ncbi.nlm.nih.gov/pubmed/37649968 http://dx.doi.org/10.1177/25158414231195174 |
_version_ | 1785098551263494144 |
---|---|
author | Akbas, Yusuf Berk Alagoz, Cengiz Cakmak, Semih Demir, Gokhan Alagoz, Nese Artunay, Halil Ozgur |
author_facet | Akbas, Yusuf Berk Alagoz, Cengiz Cakmak, Semih Demir, Gokhan Alagoz, Nese Artunay, Halil Ozgur |
author_sort | Akbas, Yusuf Berk |
collection | PubMed |
description | BACKGROUND: Diabetic macular edema (DME) is the most common cause of visual deterioration in patients with diabetes mellitus. Various treatment options have been used for DME, including intravitreal injection of steroids and anti-vascular endothelial growth factors. OBJECTIVES: To evaluate and compare the functional and anatomical outcomes of intravitreal ranibizumab (IVR) and intravitreal aflibercept (IVA) treatments in patients with DME. DESIGN: Retrospective study. METHODS: Four hundred three eyes of 235 naïve patients who underwent IVR or IVA treatment for DME followed up to 36 months included in the study. Best corrected visual acuity (BCVA) and central macular thickness (CMT) were measured at baseline, year 1, 2 and 3. Primary endpoint of the study was the change in BCVA and CMT each year from baseline and requirement of additional treatment (laser/steroid injection). RESULTS: There were 198 eyes in IVR group and 205 eyes in IVA group. The changes in mean BCVA were 0.09 ± 0.32 versus 0.17 ± 0.41 Logarithm of the minimum angle of resolution (logMAR) (p = 0.042) at year 1, 0.09 ± 0.37 versus 0.12 ± 0.45 logMAR (p = 0.512) at year 2 and 0.13 ± 0.36 versus 0.15 ± 0.48 logMAR (p = 0.824) at year 3 in IVA and IVR groups, respectively. The baseline mean BCVA were lower (p = 0.004) in IVA group. The mean total number of injections was 7.93 ± 3.38 versus 7.42 ± 3.05 (p = 0.112). CONCLUSION: At year 1, change in mean BCVA was statistically significantly higher in IVA group; however this difference did not persist at years 2 and 3. Although the mean total number of injections was similar between groups, the requirement for adjuvant steroid treatment was significantly higher in ranibizumab group, which may affect the number of visits and treatment costs. Both ranibizumab and aflibercept treatments achieved a good long-term visual and anatomical response in DME patients. |
format | Online Article Text |
id | pubmed-10464826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-104648262023-08-30 Three year outcomes of intravitreal ranibizumab and aflibercept treatment of patients with diabetic macular edema: A comparative study Akbas, Yusuf Berk Alagoz, Cengiz Cakmak, Semih Demir, Gokhan Alagoz, Nese Artunay, Halil Ozgur Ther Adv Ophthalmol Original Research BACKGROUND: Diabetic macular edema (DME) is the most common cause of visual deterioration in patients with diabetes mellitus. Various treatment options have been used for DME, including intravitreal injection of steroids and anti-vascular endothelial growth factors. OBJECTIVES: To evaluate and compare the functional and anatomical outcomes of intravitreal ranibizumab (IVR) and intravitreal aflibercept (IVA) treatments in patients with DME. DESIGN: Retrospective study. METHODS: Four hundred three eyes of 235 naïve patients who underwent IVR or IVA treatment for DME followed up to 36 months included in the study. Best corrected visual acuity (BCVA) and central macular thickness (CMT) were measured at baseline, year 1, 2 and 3. Primary endpoint of the study was the change in BCVA and CMT each year from baseline and requirement of additional treatment (laser/steroid injection). RESULTS: There were 198 eyes in IVR group and 205 eyes in IVA group. The changes in mean BCVA were 0.09 ± 0.32 versus 0.17 ± 0.41 Logarithm of the minimum angle of resolution (logMAR) (p = 0.042) at year 1, 0.09 ± 0.37 versus 0.12 ± 0.45 logMAR (p = 0.512) at year 2 and 0.13 ± 0.36 versus 0.15 ± 0.48 logMAR (p = 0.824) at year 3 in IVA and IVR groups, respectively. The baseline mean BCVA were lower (p = 0.004) in IVA group. The mean total number of injections was 7.93 ± 3.38 versus 7.42 ± 3.05 (p = 0.112). CONCLUSION: At year 1, change in mean BCVA was statistically significantly higher in IVA group; however this difference did not persist at years 2 and 3. Although the mean total number of injections was similar between groups, the requirement for adjuvant steroid treatment was significantly higher in ranibizumab group, which may affect the number of visits and treatment costs. Both ranibizumab and aflibercept treatments achieved a good long-term visual and anatomical response in DME patients. SAGE Publications 2023-08-28 /pmc/articles/PMC10464826/ /pubmed/37649968 http://dx.doi.org/10.1177/25158414231195174 Text en © The Author(s), 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Akbas, Yusuf Berk Alagoz, Cengiz Cakmak, Semih Demir, Gokhan Alagoz, Nese Artunay, Halil Ozgur Three year outcomes of intravitreal ranibizumab and aflibercept treatment of patients with diabetic macular edema: A comparative study |
title | Three year outcomes of intravitreal ranibizumab and aflibercept treatment of patients with diabetic macular edema: A comparative study |
title_full | Three year outcomes of intravitreal ranibizumab and aflibercept treatment of patients with diabetic macular edema: A comparative study |
title_fullStr | Three year outcomes of intravitreal ranibizumab and aflibercept treatment of patients with diabetic macular edema: A comparative study |
title_full_unstemmed | Three year outcomes of intravitreal ranibizumab and aflibercept treatment of patients with diabetic macular edema: A comparative study |
title_short | Three year outcomes of intravitreal ranibizumab and aflibercept treatment of patients with diabetic macular edema: A comparative study |
title_sort | three year outcomes of intravitreal ranibizumab and aflibercept treatment of patients with diabetic macular edema: a comparative study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464826/ https://www.ncbi.nlm.nih.gov/pubmed/37649968 http://dx.doi.org/10.1177/25158414231195174 |
work_keys_str_mv | AT akbasyusufberk threeyearoutcomesofintravitrealranibizumabandaflibercepttreatmentofpatientswithdiabeticmacularedemaacomparativestudy AT alagozcengiz threeyearoutcomesofintravitrealranibizumabandaflibercepttreatmentofpatientswithdiabeticmacularedemaacomparativestudy AT cakmaksemih threeyearoutcomesofintravitrealranibizumabandaflibercepttreatmentofpatientswithdiabeticmacularedemaacomparativestudy AT demirgokhan threeyearoutcomesofintravitrealranibizumabandaflibercepttreatmentofpatientswithdiabeticmacularedemaacomparativestudy AT alagoznese threeyearoutcomesofintravitrealranibizumabandaflibercepttreatmentofpatientswithdiabeticmacularedemaacomparativestudy AT artunayhalilozgur threeyearoutcomesofintravitrealranibizumabandaflibercepttreatmentofpatientswithdiabeticmacularedemaacomparativestudy |