Cargando…

Plecanatide Improves Symptoms of Irritable Bowel Syndrome with Constipation: Results of an Integrated Efficacy and Safety Analysis of Two Phase 3 Trials

PURPOSE: Patients with irritable bowel syndrome with constipation (IBS-C) experience abdominal pain with altered bowel movements. Plecanatide is indicated as IBS-C treatment in adults. This integrated analysis further characterizes plecanatide efficacy and safety in IBS-C. PATIENTS AND METHODS: Data...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brenner, Darren M, Dorn, Spencer D, Fogel, Ronald P, Christie, Jennifer, Laitman, Adam P, Rosenberg, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464888/ https://www.ncbi.nlm.nih.gov/pubmed/37649852 http://dx.doi.org/10.2147/IJGM.S400431

Ejemplares similares

Influence of Demographic Factors on Clinical Outcomes in Adults With Chronic Idiopathic Constipation Treated With Plecanatide
por: Rao, Satish S.C., et al.
Publicado: (2023)

Clinical utility of plecanatide in the treatment of chronic idiopathic constipation
por: Islam, Bianca N, et al.
Publicado: (2018)

Randomized clinical trial: efficacy and safety of plecanatide in the treatment of chronic idiopathic constipation
por: DeMicco, Michael, et al.
Publicado: (2017)

Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation
por: Rao, Satish S.C.
Publicado: (2018)

Profile of plecanatide in the treatment of chronic idiopathic constipation: design, development, and place in therapy
por: Sharma, Amol, et al.
Publicado: (2019)

A Randomized Phase III Clinical Trial of Plecanatide, a Uroguanylin Analog, in Patients With Chronic Idiopathic Constipation
por: Miner Jr, Philip B, et al.
Publicado: (2017)

Linaclotide Reduced Response Time for Irritable Bowel Syndrome With Constipation Symptoms: Analysis of 4 Randomized Controlled Trials
por: Brenner, Darren M., et al.
Publicado: (2023)

Tegaserod in the treatment of irritable bowel syndrome (IBS) with constipation as the prime symptom
por: Layer, Peter, et al.
Publicado: (2007)

Functional constipation masked as irritable bowel syndrome
por: Tosto, Monica, et al.
Publicado: (2020)

Lower and Upper Gastrointestinal Symptoms Differ Between Individuals With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation
por: Shah, Eric D, et al.
Publicado: (2018)

Review article: linaclotide for the management of irritable bowel syndrome with constipation
por: Layer, P, et al.
Publicado: (2014)

Emerging Pharmacologic Therapies for Constipation-predominant Irritable Bowel Syndrome and Chronic Constipation
por: Eswaran, Shanti, et al.
Publicado: (2014)

Review of Treatment Options for Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation
por: Patel, Sarah, et al.
Publicado: (2021)

The Effect of Tegaserod on Symptoms and Quality of Life in Korean Women with Irritable Bowel Syndrome with Constipation
por: Kim, Yong Sung, et al.
Publicado: (2010)

The Spectrum of Constipation-Predominant Irritable Bowel Syndrome and Chronic Idiopathic Constipation: US Survey Assessing Symptoms, Care Seeking, and Disease Burden
por: Heidelbaugh, Joel J, et al.
Publicado: (2015)

Constipation-Predominant Irritable Bowel Syndrome Associated to Hyperprolactinemia
por: Seretis, C., et al.
Publicado: (2011)

Optimal management of constipation associated with irritable bowel syndrome
por: Furnari, Manuele, et al.
Publicado: (2015)

Comparison of Quality of Life and Psychiatric Symptoms Between Patients With Diarrhea-Predominant Irritable Bowel Syndrome and Those With Constipation-Predominant Irritable Bowel Syndrome
por: BOUSABA, J., et al.
Publicado: (2023)

Tenapanor Treatment of Patients With Constipation-Predominant Irritable Bowel Syndrome: A Phase 2, Randomized, Placebo-Controlled Efficacy and Safety Trial
por: Chey, William D, et al.
Publicado: (2017)

Pelvic Floor Symptom Related Distress in Chronic Constipation Correlates With a Diagnosis of Irritable Bowel Syndrome With Constipation and Constipation Severity but Not Pelvic Floor Dyssynergia
por: Singh, Prashant, et al.
Publicado: (2019)

Specific foods can reduce symptoms of irritable bowel syndrome and functional constipation: a review
por: Okawa, Yohei, et al.
Publicado: (2019)

Lubiprostone for the Treatment of Adult Women with Irritable Bowel Syndrome with Constipation
por: Soubra, Mahmoud, et al.
Publicado: (2012)

White Matter Microstructural Similarity and Diversity of Functional Constipation and Constipation-predominant Irritable Bowel Syndrome
por: Nan, Jiaofen, et al.
Publicado: (2018)

Efficacy and Safety of Eluxadoline in Patients With Irritable Bowel Syndrome With Diarrhea Who Report Inadequate Symptom Control With Loperamide: RELIEF Phase 4 Study
por: Brenner, Darren M., et al.
Publicado: (2019)

Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation
por: Lam, C., et al.
Publicado: (2016)

Efficacy and Safety of Acupoint Catgut Embedding for Diarrhea-Predominant Irritable Bowel Syndrome and Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis
por: Wu, Jing, et al.
Publicado: (2020)

UK clinical experience up to 52 weeks with linaclotide for irritable bowel syndrome with constipation
por: Yiannakou, Yan, et al.
Publicado: (2018)

The Role of Food in the Treatment of Bowel Disorders: Focus on Irritable Bowel Syndrome and Functional Constipation
por: Singh, Prashant, et al.
Publicado: (2022)

Linaclotide: A New Option for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation in Adults
por: Parker, Colleen H., et al.
Publicado: (2013)

Functional Constipation and Constipation-Predominant Irritable Bowel Syndrome in the General Population: Data from the GECCO Study
por: Enck, Paul, et al.
Publicado: (2016)

Clarification of Linaclotide Pharmacology Presented in a Recent Clinical Study of Plecanatide
por: Busby, Robert W., et al.
Publicado: (2014)

Saccharomyces cerevisiae I-3856 in irritable bowel syndrome with predominant constipation
por: Mourey, Florian, et al.
Publicado: (2022)

Tegaserod for Irritable Bowel Syndrome With Constipation in Women Younger Than 65 Years Without Cardiovascular Disease: Pooled Analyses of 4 Controlled Trials
por: Shah, Eric D., et al.
Publicado: (2021)

Constipation-Predominant Irritable Bowel Syndrome (IBS-C): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms
por: Di Rosa, Claudia, et al.
Publicado: (2023)

Linaclotide: evidence for its potential use in irritable bowel syndrome and chronic constipation
por: Lee, Noel, et al.
Publicado: (2012)

Autonomic nervous system activity in constipation-predominant irritable bowel syndrome patients
por: Mazur, Marcel, et al.
Publicado: (2012)

The effect of biofeedback therapy on dyssynergic constipation in patients with or without Irritable Bowel Syndrome
por: Ahadi, Tannaz, et al.
Publicado: (2014)

Methane and Constipation-predominant Irritable Bowel Syndrome: Entwining Pillars of Emerging Neurogastroenterology
por: Bin Waqar, Syed Hamza, et al.
Publicado: (2019)

Prevalence of Subthreshold Depression Among Constipation-Predominant Irritable Bowel Syndrome Patients
por: Mokhtar, Norfilza Mohd, et al.
Publicado: (2020)

Tenapanor in the Treatment of Irritable Bowel Syndrome with Constipation: Discovery, Efficacy, and Role in Management
por: Herekar, Anam, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_f7nbb9l0ei8reetbtfirtrji1r