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BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus

Novel biomarkers are key to addressing the ongoing pandemic of type 2 diabetes mellitus. While new technologies have improved the potential of identifying such biomarkers, at the same time there is an increasing need for informed prioritization to ensure efficient downstream verification. We have bu...

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Autores principales: Lundgaard, Agnete T., Burdet, Frédéric, Siggaard, Troels, Westergaard, David, Vagiaki, Danai, Cantwell, Lisa, Röder, Timo, Vistisen, Dorte, Sparsø, Thomas, Giordano, Giuseppe N., Ibberson, Mark, Banasik, Karina, Brunak, Søren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464978/
https://www.ncbi.nlm.nih.gov/pubmed/37590326
http://dx.doi.org/10.1371/journal.pcbi.1011403
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author Lundgaard, Agnete T.
Burdet, Frédéric
Siggaard, Troels
Westergaard, David
Vagiaki, Danai
Cantwell, Lisa
Röder, Timo
Vistisen, Dorte
Sparsø, Thomas
Giordano, Giuseppe N.
Ibberson, Mark
Banasik, Karina
Brunak, Søren
author_facet Lundgaard, Agnete T.
Burdet, Frédéric
Siggaard, Troels
Westergaard, David
Vagiaki, Danai
Cantwell, Lisa
Röder, Timo
Vistisen, Dorte
Sparsø, Thomas
Giordano, Giuseppe N.
Ibberson, Mark
Banasik, Karina
Brunak, Søren
author_sort Lundgaard, Agnete T.
collection PubMed
description Novel biomarkers are key to addressing the ongoing pandemic of type 2 diabetes mellitus. While new technologies have improved the potential of identifying such biomarkers, at the same time there is an increasing need for informed prioritization to ensure efficient downstream verification. We have built BALDR, an automated pipeline for biomarker comparison and prioritization in the context of diabetes. BALDR includes protein, gene, and disease data from major public repositories, text-mining data, and human and mouse experimental data from the IMI2 RHAPSODY consortium. These data are provided as easy-to-read figures and tables enabling direct comparison of up to 20 biomarker candidates for diabetes through the public website https://baldr.cpr.ku.dk.
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spelling pubmed-104649782023-08-30 BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus Lundgaard, Agnete T. Burdet, Frédéric Siggaard, Troels Westergaard, David Vagiaki, Danai Cantwell, Lisa Röder, Timo Vistisen, Dorte Sparsø, Thomas Giordano, Giuseppe N. Ibberson, Mark Banasik, Karina Brunak, Søren PLoS Comput Biol Software Novel biomarkers are key to addressing the ongoing pandemic of type 2 diabetes mellitus. While new technologies have improved the potential of identifying such biomarkers, at the same time there is an increasing need for informed prioritization to ensure efficient downstream verification. We have built BALDR, an automated pipeline for biomarker comparison and prioritization in the context of diabetes. BALDR includes protein, gene, and disease data from major public repositories, text-mining data, and human and mouse experimental data from the IMI2 RHAPSODY consortium. These data are provided as easy-to-read figures and tables enabling direct comparison of up to 20 biomarker candidates for diabetes through the public website https://baldr.cpr.ku.dk. Public Library of Science 2023-08-17 /pmc/articles/PMC10464978/ /pubmed/37590326 http://dx.doi.org/10.1371/journal.pcbi.1011403 Text en © 2023 Lundgaard et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Software
Lundgaard, Agnete T.
Burdet, Frédéric
Siggaard, Troels
Westergaard, David
Vagiaki, Danai
Cantwell, Lisa
Röder, Timo
Vistisen, Dorte
Sparsø, Thomas
Giordano, Giuseppe N.
Ibberson, Mark
Banasik, Karina
Brunak, Søren
BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus
title BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus
title_full BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus
title_fullStr BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus
title_full_unstemmed BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus
title_short BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus
title_sort baldr: a web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464978/
https://www.ncbi.nlm.nih.gov/pubmed/37590326
http://dx.doi.org/10.1371/journal.pcbi.1011403
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