Conferring liver selectivity to a thyromimetic using a novel nanoparticle increases therapeutic efficacy in a diet-induced obesity animal model

Optimization of metabolic regulation is a promising solution for many pathologies, including obesity, dyslipidemia, type 2 diabetes, and inflammatory liver disease. Synthetic thyroid hormone mimics–based regulation of metabolic balance in the liver showed promise but was hampered by the low biocompa...

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Detalles Bibliográficos
Autores principales: Wu, Ruiling, Prachyathipsakul, Theeraphop, Zhuang, Jiaming, Liu, Hongxu, Han, Yanhui, Liu, Bin, Gong, Shuai, Qiu, Jingyi, Wong, Siu, Ribbe, Alexander, Medeiros, Jewel, Bhagabati, Jayashree, Gao, Jingjing, Wu, Peidong, Dutta, Ranit, Herrera, Roman, Faraci, Steve, Xiao, Hang, Thayumanavan, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Physical Sciences and Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465086/
https://www.ncbi.nlm.nih.gov/pubmed/37649581
http://dx.doi.org/10.1093/pnasnexus/pgad252

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