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Alkali-metal bases in catalytic hydrogen isotope exchange processes

The preparation of compounds labelled with deuterium or tritium has become an essential tool in a range of research fields. Hydrogen isotope exchange (HIE) offers direct access to said compounds, introducing these isotopes in a late stage. Even though the field has rapidly advanced with the use of t...

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Autores principales: Tortajada, Andreu, Hevia, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465149/
https://www.ncbi.nlm.nih.gov/pubmed/38013748
http://dx.doi.org/10.1039/d3cy00825h
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author Tortajada, Andreu
Hevia, Eva
author_facet Tortajada, Andreu
Hevia, Eva
author_sort Tortajada, Andreu
collection PubMed
description The preparation of compounds labelled with deuterium or tritium has become an essential tool in a range of research fields. Hydrogen isotope exchange (HIE) offers direct access to said compounds, introducing these isotopes in a late stage. Even though the field has rapidly advanced with the use of transition metal catalysis, alkali-metal bases, used as catalysts or under stoichiometric conditions, have also emerged as a viable alternative. In this minireview we describe the latest advances in the use of alkali-metal bases in HIE processes, showcasing their synthetic potential as well as current challenges in the field. It is divided in different sections based on the isotope source used, emphasizing their benefits, disadvantages and limitations. The influence on the choice of alkali-metal in these processes as well as their possible mechanistic pathways are also discussed.
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spelling pubmed-104651492023-08-30 Alkali-metal bases in catalytic hydrogen isotope exchange processes Tortajada, Andreu Hevia, Eva Catal Sci Technol Chemistry The preparation of compounds labelled with deuterium or tritium has become an essential tool in a range of research fields. Hydrogen isotope exchange (HIE) offers direct access to said compounds, introducing these isotopes in a late stage. Even though the field has rapidly advanced with the use of transition metal catalysis, alkali-metal bases, used as catalysts or under stoichiometric conditions, have also emerged as a viable alternative. In this minireview we describe the latest advances in the use of alkali-metal bases in HIE processes, showcasing their synthetic potential as well as current challenges in the field. It is divided in different sections based on the isotope source used, emphasizing their benefits, disadvantages and limitations. The influence on the choice of alkali-metal in these processes as well as their possible mechanistic pathways are also discussed. The Royal Society of Chemistry 2023-07-18 /pmc/articles/PMC10465149/ /pubmed/38013748 http://dx.doi.org/10.1039/d3cy00825h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Tortajada, Andreu
Hevia, Eva
Alkali-metal bases in catalytic hydrogen isotope exchange processes
title Alkali-metal bases in catalytic hydrogen isotope exchange processes
title_full Alkali-metal bases in catalytic hydrogen isotope exchange processes
title_fullStr Alkali-metal bases in catalytic hydrogen isotope exchange processes
title_full_unstemmed Alkali-metal bases in catalytic hydrogen isotope exchange processes
title_short Alkali-metal bases in catalytic hydrogen isotope exchange processes
title_sort alkali-metal bases in catalytic hydrogen isotope exchange processes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465149/
https://www.ncbi.nlm.nih.gov/pubmed/38013748
http://dx.doi.org/10.1039/d3cy00825h
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