Oleic acid-induced metastasis of KRAS/p53-mutant colorectal cancer relies on concurrent KRAS activation and IL-8 expression bypassing EGFR activation

Background: Multigene mutations in colorectal cancer (CRC), including KRAS, BRAF, and p53, afford high metastatic ability and resistance to EGFR-targeting therapy. Understanding the molecular mechanisms regulating anti-EGFR-resistant CRC metastasis can improve CRC therapy. This study aimed to invest...

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Detalles Bibliográficos
Autores principales: Shen, Chih-Jie, Chan, Ren-Hao, Lin, Bo-Wen, Li, Nien-Chi, Huang, Ying-Hsuan, Chang, Wen-Chang, Chen, Ben-Kuen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465226/
https://www.ncbi.nlm.nih.gov/pubmed/37649607
http://dx.doi.org/10.7150/thno.85855

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