Lys-urea-Aad, Lys-urea-Cmc and Lys-urea-Cms as potential pharmacophores for the design of PSMA-targeted radioligands to reduce off-target uptake in kidneys and salivary glands

High kidney and salivary gland uptake is a common feature of prostate-specific membrane antigen (PSMA)-targeted radioligands derived from the lysine-urea-glutamic acid (Lys-urea-Glu) pharmacophore. In this study we investigated if radioligands derived from lysine-urea-2-aminoadipic acid (Lys-urea-Aa...

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Detalles Bibliográficos
Autores principales: Kuo, Hsiou-Ting, Zhang, Zhengxing, Zhang, Chengcheng, Merkens, Helen, Tan, Ruiyan, Wong, Antonio A. W. L., Uribe, Carlos F., Bénard, François, Lin, Kuo-Shyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465233/
https://www.ncbi.nlm.nih.gov/pubmed/37649602
http://dx.doi.org/10.7150/thno.87663

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