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Risk Factors Associated with Mortality among Mechanically Ventilated Patients with Coronavirus Disease 2019 Pneumonia: A Multicenter Cohort Study in Japan (J-RECOVER Study)

OBJECTIVE: Mortality analyses of patients with coronavirus disease 2019 (COVID-19) requiring invasive mechanical ventilation in Japan are limited. The present study therefore determined the risk factors for mortality in patients with COVID-19 requiring invasive mechanical ventilation. METHODS: This...

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Autores principales: Hikone, Mayu, Shibahashi, Keita, Fukuda, Masahiro, Shimoyama, Yuichiro, Yamakawa, Kazuma, Endo, Akira, Hayakawa, Mineji, Ogura, Takayuki, Hirayama, Atsushi, Yasunaga, Hideo, Tagami, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465271/
https://www.ncbi.nlm.nih.gov/pubmed/37121748
http://dx.doi.org/10.2169/internalmedicine.1740-23
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author Hikone, Mayu
Shibahashi, Keita
Fukuda, Masahiro
Shimoyama, Yuichiro
Yamakawa, Kazuma
Endo, Akira
Hayakawa, Mineji
Ogura, Takayuki
Hirayama, Atsushi
Yasunaga, Hideo
Tagami, Takashi
author_facet Hikone, Mayu
Shibahashi, Keita
Fukuda, Masahiro
Shimoyama, Yuichiro
Yamakawa, Kazuma
Endo, Akira
Hayakawa, Mineji
Ogura, Takayuki
Hirayama, Atsushi
Yasunaga, Hideo
Tagami, Takashi
author_sort Hikone, Mayu
collection PubMed
description OBJECTIVE: Mortality analyses of patients with coronavirus disease 2019 (COVID-19) requiring invasive mechanical ventilation in Japan are limited. The present study therefore determined the risk factors for mortality in patients with COVID-19 requiring invasive mechanical ventilation. METHODS: This retrospective cohort study used the dataset from the Japanese multicenter research of COVID-19 by assembling real-word data (J-RECOVER) study that was conducted between January 1 and September 31, 2020. Independent risk factors associated with in-hospital mortality were evaluated using a multivariate logistic regression analysis. Kaplan-Meier estimates of the survival were calculated for different age groups. A subgroup analysis was performed to assess differences in survival rates according to additional risk factors, including an older age and chronic pulmonary disease. PATIENTS: A total of 561 patients were eligible. The median age was 67 (interquartile range: 56-75) years old, 442 (78.8%) were men, and 151 (26.9%) died in the hospital. RESULTS: Age, chronic pulmonary disease, and renal disease were significantly associated with in-hospital mortality. Compared with patients 18-54 years old, the adjusted odds ratios of patients 55-64, 65-74, and 75-94 years old were 3.34 (95% CI, 1.34-8.31), 7.07 (95% CI, 3.05-16.40), and 18.43 (95% CI, 7.94-42.78), respectively. CONCLUSION: Age, chronic pulmonary disease, and renal disease were independently associated with mortality in patients with COVID-19 requiring invasive mechanical ventilation, and age was the most decisive indicator of a poor prognosis. Our results may aid in formulating treatment strategies and allocating healthcare resources.
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spelling pubmed-104652712023-08-30 Risk Factors Associated with Mortality among Mechanically Ventilated Patients with Coronavirus Disease 2019 Pneumonia: A Multicenter Cohort Study in Japan (J-RECOVER Study) Hikone, Mayu Shibahashi, Keita Fukuda, Masahiro Shimoyama, Yuichiro Yamakawa, Kazuma Endo, Akira Hayakawa, Mineji Ogura, Takayuki Hirayama, Atsushi Yasunaga, Hideo Tagami, Takashi Intern Med Original Article OBJECTIVE: Mortality analyses of patients with coronavirus disease 2019 (COVID-19) requiring invasive mechanical ventilation in Japan are limited. The present study therefore determined the risk factors for mortality in patients with COVID-19 requiring invasive mechanical ventilation. METHODS: This retrospective cohort study used the dataset from the Japanese multicenter research of COVID-19 by assembling real-word data (J-RECOVER) study that was conducted between January 1 and September 31, 2020. Independent risk factors associated with in-hospital mortality were evaluated using a multivariate logistic regression analysis. Kaplan-Meier estimates of the survival were calculated for different age groups. A subgroup analysis was performed to assess differences in survival rates according to additional risk factors, including an older age and chronic pulmonary disease. PATIENTS: A total of 561 patients were eligible. The median age was 67 (interquartile range: 56-75) years old, 442 (78.8%) were men, and 151 (26.9%) died in the hospital. RESULTS: Age, chronic pulmonary disease, and renal disease were significantly associated with in-hospital mortality. Compared with patients 18-54 years old, the adjusted odds ratios of patients 55-64, 65-74, and 75-94 years old were 3.34 (95% CI, 1.34-8.31), 7.07 (95% CI, 3.05-16.40), and 18.43 (95% CI, 7.94-42.78), respectively. CONCLUSION: Age, chronic pulmonary disease, and renal disease were independently associated with mortality in patients with COVID-19 requiring invasive mechanical ventilation, and age was the most decisive indicator of a poor prognosis. Our results may aid in formulating treatment strategies and allocating healthcare resources. The Japanese Society of Internal Medicine 2023-04-28 2023-08-01 /pmc/articles/PMC10465271/ /pubmed/37121748 http://dx.doi.org/10.2169/internalmedicine.1740-23 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Hikone, Mayu
Shibahashi, Keita
Fukuda, Masahiro
Shimoyama, Yuichiro
Yamakawa, Kazuma
Endo, Akira
Hayakawa, Mineji
Ogura, Takayuki
Hirayama, Atsushi
Yasunaga, Hideo
Tagami, Takashi
Risk Factors Associated with Mortality among Mechanically Ventilated Patients with Coronavirus Disease 2019 Pneumonia: A Multicenter Cohort Study in Japan (J-RECOVER Study)
title Risk Factors Associated with Mortality among Mechanically Ventilated Patients with Coronavirus Disease 2019 Pneumonia: A Multicenter Cohort Study in Japan (J-RECOVER Study)
title_full Risk Factors Associated with Mortality among Mechanically Ventilated Patients with Coronavirus Disease 2019 Pneumonia: A Multicenter Cohort Study in Japan (J-RECOVER Study)
title_fullStr Risk Factors Associated with Mortality among Mechanically Ventilated Patients with Coronavirus Disease 2019 Pneumonia: A Multicenter Cohort Study in Japan (J-RECOVER Study)
title_full_unstemmed Risk Factors Associated with Mortality among Mechanically Ventilated Patients with Coronavirus Disease 2019 Pneumonia: A Multicenter Cohort Study in Japan (J-RECOVER Study)
title_short Risk Factors Associated with Mortality among Mechanically Ventilated Patients with Coronavirus Disease 2019 Pneumonia: A Multicenter Cohort Study in Japan (J-RECOVER Study)
title_sort risk factors associated with mortality among mechanically ventilated patients with coronavirus disease 2019 pneumonia: a multicenter cohort study in japan (j-recover study)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465271/
https://www.ncbi.nlm.nih.gov/pubmed/37121748
http://dx.doi.org/10.2169/internalmedicine.1740-23
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