Methotrexate-induced Subacute Encephalopathy That Showed No Abnormalities on Magnetic Resonance Imaging Soon after Symptom Appearance

A 21-year-old woman was diagnosed with acute lymphoblastic leukemia. After the administration of intrathecal methotrexate (MTX), the patient experienced dysarthria and paralysis for one hour. Magnetic resonance imaging (MRI) performed one hour from the onset and just before symptoms disappeared reve...

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Autores principales: Fujisawa, Haruna, Mitsui, Yurika, Narukawa, Kensuke, Shirasugi, Yukari, Komaki, Shogo, Hao, Akihito, Matsumoto, Hideyuki, Takahashi, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465289/
https://www.ncbi.nlm.nih.gov/pubmed/36476551
http://dx.doi.org/10.2169/internalmedicine.0855-22
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author Fujisawa, Haruna
Mitsui, Yurika
Narukawa, Kensuke
Shirasugi, Yukari
Komaki, Shogo
Hao, Akihito
Matsumoto, Hideyuki
Takahashi, Tsuyoshi
author_facet Fujisawa, Haruna
Mitsui, Yurika
Narukawa, Kensuke
Shirasugi, Yukari
Komaki, Shogo
Hao, Akihito
Matsumoto, Hideyuki
Takahashi, Tsuyoshi
author_sort Fujisawa, Haruna
collection PubMed
description A 21-year-old woman was diagnosed with acute lymphoblastic leukemia. After the administration of intrathecal methotrexate (MTX), the patient experienced dysarthria and paralysis for one hour. Magnetic resonance imaging (MRI) performed one hour from the onset and just before symptoms disappeared revealed no abnormalities. The next day, the symptoms appeared again, and diffusion-weighed MRI revealed a high-intensity area in the left frontal lobe. The patient was diagnosed with MTX-induced encephalopathy. This case suggested that MRI performed as soon as symptoms appear might show normal findings in MTX-induced encephalopathy.
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spelling pubmed-104652892023-08-30 Methotrexate-induced Subacute Encephalopathy That Showed No Abnormalities on Magnetic Resonance Imaging Soon after Symptom Appearance Fujisawa, Haruna Mitsui, Yurika Narukawa, Kensuke Shirasugi, Yukari Komaki, Shogo Hao, Akihito Matsumoto, Hideyuki Takahashi, Tsuyoshi Intern Med Case Report A 21-year-old woman was diagnosed with acute lymphoblastic leukemia. After the administration of intrathecal methotrexate (MTX), the patient experienced dysarthria and paralysis for one hour. Magnetic resonance imaging (MRI) performed one hour from the onset and just before symptoms disappeared revealed no abnormalities. The next day, the symptoms appeared again, and diffusion-weighed MRI revealed a high-intensity area in the left frontal lobe. The patient was diagnosed with MTX-induced encephalopathy. This case suggested that MRI performed as soon as symptoms appear might show normal findings in MTX-induced encephalopathy. The Japanese Society of Internal Medicine 2022-12-07 2023-08-01 /pmc/articles/PMC10465289/ /pubmed/36476551 http://dx.doi.org/10.2169/internalmedicine.0855-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Fujisawa, Haruna
Mitsui, Yurika
Narukawa, Kensuke
Shirasugi, Yukari
Komaki, Shogo
Hao, Akihito
Matsumoto, Hideyuki
Takahashi, Tsuyoshi
Methotrexate-induced Subacute Encephalopathy That Showed No Abnormalities on Magnetic Resonance Imaging Soon after Symptom Appearance
title Methotrexate-induced Subacute Encephalopathy That Showed No Abnormalities on Magnetic Resonance Imaging Soon after Symptom Appearance
title_full Methotrexate-induced Subacute Encephalopathy That Showed No Abnormalities on Magnetic Resonance Imaging Soon after Symptom Appearance
title_fullStr Methotrexate-induced Subacute Encephalopathy That Showed No Abnormalities on Magnetic Resonance Imaging Soon after Symptom Appearance
title_full_unstemmed Methotrexate-induced Subacute Encephalopathy That Showed No Abnormalities on Magnetic Resonance Imaging Soon after Symptom Appearance
title_short Methotrexate-induced Subacute Encephalopathy That Showed No Abnormalities on Magnetic Resonance Imaging Soon after Symptom Appearance
title_sort methotrexate-induced subacute encephalopathy that showed no abnormalities on magnetic resonance imaging soon after symptom appearance
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465289/
https://www.ncbi.nlm.nih.gov/pubmed/36476551
http://dx.doi.org/10.2169/internalmedicine.0855-22
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