Autoimmune Pulmonary Alveolar Proteinosis That Improved after a COVID-19 Episode

Autoimmune pulmonary alveolar proteinosis (APAP) is caused by macrophage dysfunction owing to the presence of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies. A 77-year-old man with APAP was referred to our hospital for whole-lung lavage (WLL) due to oxygenation exacerb...

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Autores principales: Yanagisawa, Atsushi, Takimoto, Takayuki, Shintani, Ryota, Kobayashi, Takehiko, Hirose, Masaki, Arai, Toru, Inoue, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465295/
https://www.ncbi.nlm.nih.gov/pubmed/37164675
http://dx.doi.org/10.2169/internalmedicine.1592-23
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author Yanagisawa, Atsushi
Takimoto, Takayuki
Shintani, Ryota
Kobayashi, Takehiko
Hirose, Masaki
Arai, Toru
Inoue, Yoshikazu
author_facet Yanagisawa, Atsushi
Takimoto, Takayuki
Shintani, Ryota
Kobayashi, Takehiko
Hirose, Masaki
Arai, Toru
Inoue, Yoshikazu
author_sort Yanagisawa, Atsushi
collection PubMed
description Autoimmune pulmonary alveolar proteinosis (APAP) is caused by macrophage dysfunction owing to the presence of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies. A 77-year-old man with APAP was referred to our hospital for whole-lung lavage (WLL) due to oxygenation exacerbation and pulmonary shadows. The patient had had coronavirus disease 2019 (COVID-19) during the APAP evaluation before WLL. About three months after COVID-19 resolved, his oxygenation and shadow reflecting APAP had obviously improved, thus avoiding the need for WLL. We suspected that the improvement in APAP was due to various immunological reactions induced by COVID-19.
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spelling pubmed-104652952023-08-30 Autoimmune Pulmonary Alveolar Proteinosis That Improved after a COVID-19 Episode Yanagisawa, Atsushi Takimoto, Takayuki Shintani, Ryota Kobayashi, Takehiko Hirose, Masaki Arai, Toru Inoue, Yoshikazu Intern Med Case Report Autoimmune pulmonary alveolar proteinosis (APAP) is caused by macrophage dysfunction owing to the presence of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies. A 77-year-old man with APAP was referred to our hospital for whole-lung lavage (WLL) due to oxygenation exacerbation and pulmonary shadows. The patient had had coronavirus disease 2019 (COVID-19) during the APAP evaluation before WLL. About three months after COVID-19 resolved, his oxygenation and shadow reflecting APAP had obviously improved, thus avoiding the need for WLL. We suspected that the improvement in APAP was due to various immunological reactions induced by COVID-19. The Japanese Society of Internal Medicine 2023-05-10 2023-08-01 /pmc/articles/PMC10465295/ /pubmed/37164675 http://dx.doi.org/10.2169/internalmedicine.1592-23 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yanagisawa, Atsushi
Takimoto, Takayuki
Shintani, Ryota
Kobayashi, Takehiko
Hirose, Masaki
Arai, Toru
Inoue, Yoshikazu
Autoimmune Pulmonary Alveolar Proteinosis That Improved after a COVID-19 Episode
title Autoimmune Pulmonary Alveolar Proteinosis That Improved after a COVID-19 Episode
title_full Autoimmune Pulmonary Alveolar Proteinosis That Improved after a COVID-19 Episode
title_fullStr Autoimmune Pulmonary Alveolar Proteinosis That Improved after a COVID-19 Episode
title_full_unstemmed Autoimmune Pulmonary Alveolar Proteinosis That Improved after a COVID-19 Episode
title_short Autoimmune Pulmonary Alveolar Proteinosis That Improved after a COVID-19 Episode
title_sort autoimmune pulmonary alveolar proteinosis that improved after a covid-19 episode
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465295/
https://www.ncbi.nlm.nih.gov/pubmed/37164675
http://dx.doi.org/10.2169/internalmedicine.1592-23
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