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Esmethadone-HCl (REL-1017): a promising rapid antidepressant

This review article presents select recent studies that form the basis for the development of esmethadone into a potential new drug. Esmethadone is a promising member of the pharmacological class of uncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonists that have shown efficacy for major de...

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Autores principales: Fava, Maurizio, Stahl, Stephen M., De Martin, Sara, Mattarei, Andrea, Bettini, Ezio, Comai, Stefano, Alimonti, Andrea, Bifari, Francesco, Pani, Luca, Folli, Franco, Guidetti, Clotilde, Furlan, Alberto, Sgrignani, Jacopo, Locatelli, Patrizia, Cavalli, Andrea, O’Gorman, Cedric, Traversa, Sergio, Inturrisi, Charles E., Pappagallo, Marco, Manfredi, Paolo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465385/
https://www.ncbi.nlm.nih.gov/pubmed/36890259
http://dx.doi.org/10.1007/s00406-023-01571-4
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author Fava, Maurizio
Stahl, Stephen M.
De Martin, Sara
Mattarei, Andrea
Bettini, Ezio
Comai, Stefano
Alimonti, Andrea
Bifari, Francesco
Pani, Luca
Folli, Franco
Guidetti, Clotilde
Furlan, Alberto
Sgrignani, Jacopo
Locatelli, Patrizia
Cavalli, Andrea
O’Gorman, Cedric
Traversa, Sergio
Inturrisi, Charles E.
Pappagallo, Marco
Manfredi, Paolo L.
author_facet Fava, Maurizio
Stahl, Stephen M.
De Martin, Sara
Mattarei, Andrea
Bettini, Ezio
Comai, Stefano
Alimonti, Andrea
Bifari, Francesco
Pani, Luca
Folli, Franco
Guidetti, Clotilde
Furlan, Alberto
Sgrignani, Jacopo
Locatelli, Patrizia
Cavalli, Andrea
O’Gorman, Cedric
Traversa, Sergio
Inturrisi, Charles E.
Pappagallo, Marco
Manfredi, Paolo L.
author_sort Fava, Maurizio
collection PubMed
description This review article presents select recent studies that form the basis for the development of esmethadone into a potential new drug. Esmethadone is a promising member of the pharmacological class of uncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonists that have shown efficacy for major depressive disorder (MDD) and other diseases and disorders, such as Alzheimer’s dementia and pseudobulbar affect. The other drugs in the novel class of NMDAR antagonists with therapeutic uses that are discussed for comparative purposes in this review are esketamine, ketamine, dextromethorphan, and memantine. We present in silico, in vitro, in vivo, and clinical data for esmethadone and other uncompetitive NMDAR antagonists that may advance our understanding of the role of these receptors in neural plasticity in health and disease. The efficacy of NMDAR antagonists as rapid antidepressants may advance our understanding of the neurobiology of MDD and other neuropsychiatric diseases and disorders.
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spelling pubmed-104653852023-08-31 Esmethadone-HCl (REL-1017): a promising rapid antidepressant Fava, Maurizio Stahl, Stephen M. De Martin, Sara Mattarei, Andrea Bettini, Ezio Comai, Stefano Alimonti, Andrea Bifari, Francesco Pani, Luca Folli, Franco Guidetti, Clotilde Furlan, Alberto Sgrignani, Jacopo Locatelli, Patrizia Cavalli, Andrea O’Gorman, Cedric Traversa, Sergio Inturrisi, Charles E. Pappagallo, Marco Manfredi, Paolo L. Eur Arch Psychiatry Clin Neurosci Invited Review This review article presents select recent studies that form the basis for the development of esmethadone into a potential new drug. Esmethadone is a promising member of the pharmacological class of uncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonists that have shown efficacy for major depressive disorder (MDD) and other diseases and disorders, such as Alzheimer’s dementia and pseudobulbar affect. The other drugs in the novel class of NMDAR antagonists with therapeutic uses that are discussed for comparative purposes in this review are esketamine, ketamine, dextromethorphan, and memantine. We present in silico, in vitro, in vivo, and clinical data for esmethadone and other uncompetitive NMDAR antagonists that may advance our understanding of the role of these receptors in neural plasticity in health and disease. The efficacy of NMDAR antagonists as rapid antidepressants may advance our understanding of the neurobiology of MDD and other neuropsychiatric diseases and disorders. Springer Berlin Heidelberg 2023-03-08 2023 /pmc/articles/PMC10465385/ /pubmed/36890259 http://dx.doi.org/10.1007/s00406-023-01571-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Invited Review
Fava, Maurizio
Stahl, Stephen M.
De Martin, Sara
Mattarei, Andrea
Bettini, Ezio
Comai, Stefano
Alimonti, Andrea
Bifari, Francesco
Pani, Luca
Folli, Franco
Guidetti, Clotilde
Furlan, Alberto
Sgrignani, Jacopo
Locatelli, Patrizia
Cavalli, Andrea
O’Gorman, Cedric
Traversa, Sergio
Inturrisi, Charles E.
Pappagallo, Marco
Manfredi, Paolo L.
Esmethadone-HCl (REL-1017): a promising rapid antidepressant
title Esmethadone-HCl (REL-1017): a promising rapid antidepressant
title_full Esmethadone-HCl (REL-1017): a promising rapid antidepressant
title_fullStr Esmethadone-HCl (REL-1017): a promising rapid antidepressant
title_full_unstemmed Esmethadone-HCl (REL-1017): a promising rapid antidepressant
title_short Esmethadone-HCl (REL-1017): a promising rapid antidepressant
title_sort esmethadone-hcl (rel-1017): a promising rapid antidepressant
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465385/
https://www.ncbi.nlm.nih.gov/pubmed/36890259
http://dx.doi.org/10.1007/s00406-023-01571-4
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