Single-cell sequencing of a novel model of neonatal bile duct ligation in mice identifies macrophage heterogeneity in obstructive cholestasis

Macrophages (MΦ) play a role in neonatal etiologies of obstructive cholestasis, however, the role for precise MΦ subsets remains poorly defined. We developed a neonatal murine model of bile duct ligation (BDL) to characterize etiology-specific differences in neonatal cholestatic MΦ polarization. Neo...

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Detalles Bibliográficos
Autores principales: Antala, Swati, Gromer, Kyle D., Gadhvi, Gaurav, Kriegermeier, Alyssa, Wang, Jiao-Jing, Abdala-Valencia, Hiam, Wechsler, Joshua B., Perlman, Harris, Winter, Deborah R., Zhang, Zheng J., Green, Richard M., Taylor, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465511/
https://www.ncbi.nlm.nih.gov/pubmed/37644108
http://dx.doi.org/10.1038/s41598-023-41207-0

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