Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction

Cardiovascular diseases are the leading cause of death worldwide and are not typically diagnosed until the disease has manifested. Endothelial dysfunction is an early, reversible precursor in the irreversible development of cardiovascular diseases and is characterized by a decrease in nitric oxide p...

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Autores principales: Andreeva, Valeriia D., Ehlers, Haley, R. C., Aswin Krishna, Presselt, Martin, J. van den Broek, Lenie, Bonnet, Sylvestre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465535/
https://www.ncbi.nlm.nih.gov/pubmed/37644120
http://dx.doi.org/10.1038/s42004-023-00973-8
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author Andreeva, Valeriia D.
Ehlers, Haley
R. C., Aswin Krishna
Presselt, Martin
J. van den Broek, Lenie
Bonnet, Sylvestre
author_facet Andreeva, Valeriia D.
Ehlers, Haley
R. C., Aswin Krishna
Presselt, Martin
J. van den Broek, Lenie
Bonnet, Sylvestre
author_sort Andreeva, Valeriia D.
collection PubMed
description Cardiovascular diseases are the leading cause of death worldwide and are not typically diagnosed until the disease has manifested. Endothelial dysfunction is an early, reversible precursor in the irreversible development of cardiovascular diseases and is characterized by a decrease in nitric oxide production. We believe that more reliable and reproducible methods are necessary for the detection of endothelial dysfunction. Both nitric oxide and calcium play important roles in the endothelial function. Here we review different types of molecular sensors used in biological settings. Next, we review the current nitric oxide and calcium sensors available. Finally, we review methods for using both sensors for the detection of endothelial dysfunction.
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spelling pubmed-104655352023-08-31 Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction Andreeva, Valeriia D. Ehlers, Haley R. C., Aswin Krishna Presselt, Martin J. van den Broek, Lenie Bonnet, Sylvestre Commun Chem Review Article Cardiovascular diseases are the leading cause of death worldwide and are not typically diagnosed until the disease has manifested. Endothelial dysfunction is an early, reversible precursor in the irreversible development of cardiovascular diseases and is characterized by a decrease in nitric oxide production. We believe that more reliable and reproducible methods are necessary for the detection of endothelial dysfunction. Both nitric oxide and calcium play important roles in the endothelial function. Here we review different types of molecular sensors used in biological settings. Next, we review the current nitric oxide and calcium sensors available. Finally, we review methods for using both sensors for the detection of endothelial dysfunction. Nature Publishing Group UK 2023-08-29 /pmc/articles/PMC10465535/ /pubmed/37644120 http://dx.doi.org/10.1038/s42004-023-00973-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Andreeva, Valeriia D.
Ehlers, Haley
R. C., Aswin Krishna
Presselt, Martin
J. van den Broek, Lenie
Bonnet, Sylvestre
Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction
title Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction
title_full Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction
title_fullStr Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction
title_full_unstemmed Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction
title_short Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction
title_sort combining nitric oxide and calcium sensing for the detection of endothelial dysfunction
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465535/
https://www.ncbi.nlm.nih.gov/pubmed/37644120
http://dx.doi.org/10.1038/s42004-023-00973-8
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