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Downregulation of transposable elements extends lifespan in Caenorhabditis elegans

Mobility of transposable elements (TEs) frequently leads to insertional mutations in functional DNA regions. In the potentially immortal germline, TEs are effectively suppressed by the Piwi-piRNA pathway. However, in the genomes of ageing somatic cells lacking the effects of the pathway, TEs become...

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Detalles Bibliográficos
Autores principales:	Sturm, Ádám, Saskői, Éva, Hotzi, Bernadette, Tarnóci, Anna, Barna, János, Bodnár, Ferenc, Sharma, Himani, Kovács, Tibor, Ari, Eszter, Weinhardt, Nóra, Kerepesi, Csaba, Perczel, András, Ivics, Zoltán, Vellai, Tibor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465613/ https://www.ncbi.nlm.nih.gov/pubmed/37644049 http://dx.doi.org/10.1038/s41467-023-40957-9

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