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Are sleep disorders associated with the risk of gastrointestinal cancer?—A case–control study
PURPOSE: Sleep disorders are among the most common health problems worldwide and are linked to a variety of physical and mental health problems. Recently, there has been increasing evidence of an association between sleep disorders and cancer risk. We aimed to investigate this association specifical...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465665/ https://www.ncbi.nlm.nih.gov/pubmed/37378673 http://dx.doi.org/10.1007/s00432-023-05009-1 |
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author | Loosen, Sven Krieg, Sarah Krieg, Andreas Leyh, Catherine Luedde, Tom Vetter, Céline Kostev, Karel Roderburg, Christoph |
author_facet | Loosen, Sven Krieg, Sarah Krieg, Andreas Leyh, Catherine Luedde, Tom Vetter, Céline Kostev, Karel Roderburg, Christoph |
author_sort | Loosen, Sven |
collection | PubMed |
description | PURPOSE: Sleep disorders are among the most common health problems worldwide and are linked to a variety of physical and mental health problems. Recently, there has been increasing evidence of an association between sleep disorders and cancer risk. We aimed to investigate this association specifically for cancers of the gastrointestinal (GI) tract. METHODS: Using the DA database (IQVIA), adult patients diagnosed with GI cancer between January 2010 and December 2022 were retrospectively compared to a 1:1 propensity score-matched cohort of patients without cancer. The outcome of the study was the association between sleep disorders and subsequent diagnosis of GI cancer. To determine whether sleep disorders were more common in patients with GI cancer than in patients without GI cancer, logistic regression models were used to estimate odds ratios (ORs) with 95% confidence intervals (95% CI). RESULTS: After matching, 37,161 cases with GI cancer and 37,161 controls without cancer were available for analysis. No association with cancer was found for sleep disorders in the overall history before the index date (OR 1.04; 95% CI 0.96–1.12), but considering sleep disorders documented within 1 year before the index date showed a positive association with GI cancer overall (OR 1.20; 95% CI 1.08–1.34). Stratified analyses by cancer site revealed higher odds of sleep disorders prior to diagnosis of gastric, pancreatic, and colorectal cancer. CONCLUSION: Our findings suggest that sleep disorders might be indicative of short-term health outcomes, including GI cancer, suggesting a role for sleep disorder screening in the context of cancer prevention efforts. |
format | Online Article Text |
id | pubmed-10465665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-104656652023-08-31 Are sleep disorders associated with the risk of gastrointestinal cancer?—A case–control study Loosen, Sven Krieg, Sarah Krieg, Andreas Leyh, Catherine Luedde, Tom Vetter, Céline Kostev, Karel Roderburg, Christoph J Cancer Res Clin Oncol Research PURPOSE: Sleep disorders are among the most common health problems worldwide and are linked to a variety of physical and mental health problems. Recently, there has been increasing evidence of an association between sleep disorders and cancer risk. We aimed to investigate this association specifically for cancers of the gastrointestinal (GI) tract. METHODS: Using the DA database (IQVIA), adult patients diagnosed with GI cancer between January 2010 and December 2022 were retrospectively compared to a 1:1 propensity score-matched cohort of patients without cancer. The outcome of the study was the association between sleep disorders and subsequent diagnosis of GI cancer. To determine whether sleep disorders were more common in patients with GI cancer than in patients without GI cancer, logistic regression models were used to estimate odds ratios (ORs) with 95% confidence intervals (95% CI). RESULTS: After matching, 37,161 cases with GI cancer and 37,161 controls without cancer were available for analysis. No association with cancer was found for sleep disorders in the overall history before the index date (OR 1.04; 95% CI 0.96–1.12), but considering sleep disorders documented within 1 year before the index date showed a positive association with GI cancer overall (OR 1.20; 95% CI 1.08–1.34). Stratified analyses by cancer site revealed higher odds of sleep disorders prior to diagnosis of gastric, pancreatic, and colorectal cancer. CONCLUSION: Our findings suggest that sleep disorders might be indicative of short-term health outcomes, including GI cancer, suggesting a role for sleep disorder screening in the context of cancer prevention efforts. Springer Berlin Heidelberg 2023-06-28 2023 /pmc/articles/PMC10465665/ /pubmed/37378673 http://dx.doi.org/10.1007/s00432-023-05009-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Loosen, Sven Krieg, Sarah Krieg, Andreas Leyh, Catherine Luedde, Tom Vetter, Céline Kostev, Karel Roderburg, Christoph Are sleep disorders associated with the risk of gastrointestinal cancer?—A case–control study |
title | Are sleep disorders associated with the risk of gastrointestinal cancer?—A case–control study |
title_full | Are sleep disorders associated with the risk of gastrointestinal cancer?—A case–control study |
title_fullStr | Are sleep disorders associated with the risk of gastrointestinal cancer?—A case–control study |
title_full_unstemmed | Are sleep disorders associated with the risk of gastrointestinal cancer?—A case–control study |
title_short | Are sleep disorders associated with the risk of gastrointestinal cancer?—A case–control study |
title_sort | are sleep disorders associated with the risk of gastrointestinal cancer?—a case–control study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465665/ https://www.ncbi.nlm.nih.gov/pubmed/37378673 http://dx.doi.org/10.1007/s00432-023-05009-1 |
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