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Post acute CoViD-19 syndrome (PACS) - Long CoViD
Patients sero-positive for the Systemic Acute Respiratory Syndrome Corona virus2 (SARS-CoV2) virus develop the Corona Virus Disease 2019 (CoViD-19). CoViD-19 may be asymptomatic in some individuals, proffer mild symptoms in other patients, and can be a serious and even lethal disease in a sub-group...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Biomedical Informatics
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465760/ https://www.ncbi.nlm.nih.gov/pubmed/37654836 http://dx.doi.org/10.6026/97320630018908 |
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author | Chiappelli, Francesco Fotovat, Lily |
author_facet | Chiappelli, Francesco Fotovat, Lily |
author_sort | Chiappelli, Francesco |
collection | PubMed |
description | Patients sero-positive for the Systemic Acute Respiratory Syndrome Corona virus2 (SARS-CoV2) virus develop the Corona Virus Disease 2019 (CoViD-19). CoViD-19 may be asymptomatic in some individuals, proffer mild symptoms in other patients, and can be a serious and even lethal disease in a sub-group of the population. The variables that determine the severity of CoViD-19 have not been fully characterized. What is clear is that the patients who survive CoViD-19 return to a state of sero-negativity for SARS-CoV2 generally within 3-5 weeks. However, several cases of repeated infection have been reported, and a large proportion of CoViD-19-recovered patients manifest multi-system and multi-organ symptomatic pathologies several weeks-to-months after resuming sero-negativity for SARS-CoV2. This new pathological condition, originally termed Long Covid, is now recognized as the Post Acute CoViD-19 Syndrome (PACS). The original principal clusters of signs and symptoms of PACS: likelihood of relapse and reinfection, physical fatigue and cognitive slowdown, may actually be broadened to include immune deregulation, cardiovascular disease and coagulation abnormalities. The development and evaluation of new and improved clinical interventions for PACS are critical and timely. |
format | Online Article Text |
id | pubmed-10465760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-104657602023-08-31 Post acute CoViD-19 syndrome (PACS) - Long CoViD Chiappelli, Francesco Fotovat, Lily Bioinformation Editorial Patients sero-positive for the Systemic Acute Respiratory Syndrome Corona virus2 (SARS-CoV2) virus develop the Corona Virus Disease 2019 (CoViD-19). CoViD-19 may be asymptomatic in some individuals, proffer mild symptoms in other patients, and can be a serious and even lethal disease in a sub-group of the population. The variables that determine the severity of CoViD-19 have not been fully characterized. What is clear is that the patients who survive CoViD-19 return to a state of sero-negativity for SARS-CoV2 generally within 3-5 weeks. However, several cases of repeated infection have been reported, and a large proportion of CoViD-19-recovered patients manifest multi-system and multi-organ symptomatic pathologies several weeks-to-months after resuming sero-negativity for SARS-CoV2. This new pathological condition, originally termed Long Covid, is now recognized as the Post Acute CoViD-19 Syndrome (PACS). The original principal clusters of signs and symptoms of PACS: likelihood of relapse and reinfection, physical fatigue and cognitive slowdown, may actually be broadened to include immune deregulation, cardiovascular disease and coagulation abnormalities. The development and evaluation of new and improved clinical interventions for PACS are critical and timely. Biomedical Informatics 2022-10-31 /pmc/articles/PMC10465760/ /pubmed/37654836 http://dx.doi.org/10.6026/97320630018908 Text en © 2022 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Editorial Chiappelli, Francesco Fotovat, Lily Post acute CoViD-19 syndrome (PACS) - Long CoViD |
title | Post acute CoViD-19 syndrome (PACS) - Long CoViD |
title_full | Post acute CoViD-19 syndrome (PACS) - Long CoViD |
title_fullStr | Post acute CoViD-19 syndrome (PACS) - Long CoViD |
title_full_unstemmed | Post acute CoViD-19 syndrome (PACS) - Long CoViD |
title_short | Post acute CoViD-19 syndrome (PACS) - Long CoViD |
title_sort | post acute covid-19 syndrome (pacs) - long covid |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465760/ https://www.ncbi.nlm.nih.gov/pubmed/37654836 http://dx.doi.org/10.6026/97320630018908 |
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