Anti-cancer activity of C. cainito leaves explained using its compounds docked with p53

Extensive research on the mutant P53 protein has identified its pivotal role in anti-apoptosis mechanisms, drug resistance, and cancer progression in OSCC. The mass spectrum revealed the pharmacologically significant bioactive compounds reported for the first time in C cainito. Molecular docking inv...

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Detalles Bibliográficos
Autores principales: Prabhu, Yesudass Antony, Balalakshmi, Chinnasamy, Vijayasarathy, Muthu, Kumar, Kumar Praveen, Shanmughavel, Piramanayagam, Kavitha, Samiappan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465767/
https://www.ncbi.nlm.nih.gov/pubmed/37654835
http://dx.doi.org/10.6026/97320630018870
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author Prabhu, Yesudass Antony
Balalakshmi, Chinnasamy
Vijayasarathy, Muthu
Kumar, Kumar Praveen
Shanmughavel, Piramanayagam
Kavitha, Samiappan
author_facet Prabhu, Yesudass Antony
Balalakshmi, Chinnasamy
Vijayasarathy, Muthu
Kumar, Kumar Praveen
Shanmughavel, Piramanayagam
Kavitha, Samiappan
author_sort Prabhu, Yesudass Antony
collection PubMed
description Extensive research on the mutant P53 protein has identified its pivotal role in anti-apoptosis mechanisms, drug resistance, and cancer progression in OSCC. The mass spectrum revealed the pharmacologically significant bioactive compounds reported for the first time in C cainito. Molecular docking investigation has identified four potential new P53 inhibitors compared with the standard P53 inhibitors. Hence, this analysis reinforces the likelihood of anti-cancer activities in C. cainito leaves.
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spelling pubmed-104657672023-08-31 Anti-cancer activity of C. cainito leaves explained using its compounds docked with p53 Prabhu, Yesudass Antony Balalakshmi, Chinnasamy Vijayasarathy, Muthu Kumar, Kumar Praveen Shanmughavel, Piramanayagam Kavitha, Samiappan Bioinformation Research Article Extensive research on the mutant P53 protein has identified its pivotal role in anti-apoptosis mechanisms, drug resistance, and cancer progression in OSCC. The mass spectrum revealed the pharmacologically significant bioactive compounds reported for the first time in C cainito. Molecular docking investigation has identified four potential new P53 inhibitors compared with the standard P53 inhibitors. Hence, this analysis reinforces the likelihood of anti-cancer activities in C. cainito leaves. Biomedical Informatics 2022-10-31 /pmc/articles/PMC10465767/ /pubmed/37654835 http://dx.doi.org/10.6026/97320630018870 Text en © 2022 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Prabhu, Yesudass Antony
Balalakshmi, Chinnasamy
Vijayasarathy, Muthu
Kumar, Kumar Praveen
Shanmughavel, Piramanayagam
Kavitha, Samiappan
Anti-cancer activity of C. cainito leaves explained using its compounds docked with p53
title Anti-cancer activity of C. cainito leaves explained using its compounds docked with p53
title_full Anti-cancer activity of C. cainito leaves explained using its compounds docked with p53
title_fullStr Anti-cancer activity of C. cainito leaves explained using its compounds docked with p53
title_full_unstemmed Anti-cancer activity of C. cainito leaves explained using its compounds docked with p53
title_short Anti-cancer activity of C. cainito leaves explained using its compounds docked with p53
title_sort anti-cancer activity of c. cainito leaves explained using its compounds docked with p53
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465767/
https://www.ncbi.nlm.nih.gov/pubmed/37654835
http://dx.doi.org/10.6026/97320630018870
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