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The emerging role of E3 ubiquitin ligase RNF213 as an antimicrobial host determinant

Ring finger protein 213 (RNF213) is a large E3 ubiquitin ligase with a molecular weight of 591 kDa that is associated with moyamoya disease, a rare cerebrovascular disease. It is located in the cytosol and perinuclear space. Missense mutations in this gene have been found to be more prevalent in pat...

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Autores principales: Zhang, Yulu, Yuan, Yupei, Jiang, Lu, Liu, Yihan, Zhang, Leiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465799/
https://www.ncbi.nlm.nih.gov/pubmed/37655297
http://dx.doi.org/10.3389/fcimb.2023.1205355
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author Zhang, Yulu
Yuan, Yupei
Jiang, Lu
Liu, Yihan
Zhang, Leiliang
author_facet Zhang, Yulu
Yuan, Yupei
Jiang, Lu
Liu, Yihan
Zhang, Leiliang
author_sort Zhang, Yulu
collection PubMed
description Ring finger protein 213 (RNF213) is a large E3 ubiquitin ligase with a molecular weight of 591 kDa that is associated with moyamoya disease, a rare cerebrovascular disease. It is located in the cytosol and perinuclear space. Missense mutations in this gene have been found to be more prevalent in patients with moyamoya disease compared with that in healthy individuals. Understanding the molecular function of RNF213 could provide insights into moyamoya disease. RNF213 contains a C3HC4-type RING finger domain with an E3 ubiquitin ligase domain and six AAA+ adenosine triphosphatase (ATPase) domains. It is the only known protein with both AAA+ ATPase and ubiquitin ligase activities. Recent studies have highlighted the role of RNF213 in fighting against microbial infections, including viruses, parasites, bacteria, and chlamydiae. This review aims to summarize the recent research progress on the mechanisms of RNF213 in pathogenic infections, which will aid researchers in understanding the antimicrobial role of RNF213.
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spelling pubmed-104657992023-08-31 The emerging role of E3 ubiquitin ligase RNF213 as an antimicrobial host determinant Zhang, Yulu Yuan, Yupei Jiang, Lu Liu, Yihan Zhang, Leiliang Front Cell Infect Microbiol Cellular and Infection Microbiology Ring finger protein 213 (RNF213) is a large E3 ubiquitin ligase with a molecular weight of 591 kDa that is associated with moyamoya disease, a rare cerebrovascular disease. It is located in the cytosol and perinuclear space. Missense mutations in this gene have been found to be more prevalent in patients with moyamoya disease compared with that in healthy individuals. Understanding the molecular function of RNF213 could provide insights into moyamoya disease. RNF213 contains a C3HC4-type RING finger domain with an E3 ubiquitin ligase domain and six AAA+ adenosine triphosphatase (ATPase) domains. It is the only known protein with both AAA+ ATPase and ubiquitin ligase activities. Recent studies have highlighted the role of RNF213 in fighting against microbial infections, including viruses, parasites, bacteria, and chlamydiae. This review aims to summarize the recent research progress on the mechanisms of RNF213 in pathogenic infections, which will aid researchers in understanding the antimicrobial role of RNF213. Frontiers Media S.A. 2023-08-15 /pmc/articles/PMC10465799/ /pubmed/37655297 http://dx.doi.org/10.3389/fcimb.2023.1205355 Text en Copyright © 2023 Zhang, Yuan, Jiang, Liu and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Zhang, Yulu
Yuan, Yupei
Jiang, Lu
Liu, Yihan
Zhang, Leiliang
The emerging role of E3 ubiquitin ligase RNF213 as an antimicrobial host determinant
title The emerging role of E3 ubiquitin ligase RNF213 as an antimicrobial host determinant
title_full The emerging role of E3 ubiquitin ligase RNF213 as an antimicrobial host determinant
title_fullStr The emerging role of E3 ubiquitin ligase RNF213 as an antimicrobial host determinant
title_full_unstemmed The emerging role of E3 ubiquitin ligase RNF213 as an antimicrobial host determinant
title_short The emerging role of E3 ubiquitin ligase RNF213 as an antimicrobial host determinant
title_sort emerging role of e3 ubiquitin ligase rnf213 as an antimicrobial host determinant
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465799/
https://www.ncbi.nlm.nih.gov/pubmed/37655297
http://dx.doi.org/10.3389/fcimb.2023.1205355
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