Development of a bicistronic anti-CD19/CD20 CAR construct including abrogation of unexpected nucleic acid sequence deletions

To address CD19 loss from lymphoma after anti-CD19 chimeric antigen receptor (CAR) T cell therapy, we designed a bicistronic construct encoding an anti-CD19 CAR and an anti-CD20 CAR. We detected deletions from the expected bicistronic construct sequence in a minority of transcripts by mRNA sequencin...

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Detalles Bibliográficos
Autores principales: Lam, Norris, Finney, Richard, Yang, Shicheng, Choi, Stephanie, Wu, Xiaolin, Cutmore, Lauren, Andrade, Jorge, Huang, Lei, Amatya, Christina, Cam, Margaret, Kochenderfer, James N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465854/
https://www.ncbi.nlm.nih.gov/pubmed/37654973
http://dx.doi.org/10.1016/j.omto.2023.07.001

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