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The use of Ephedra herbs in the treatment of COVID-19

OBJECTIVE: Ephedra herbs are the only extant genus in its family, Ephedraceae, and order, Ephedrales. It has been prescribed in traditional medicine for improving headaches and respiratory infections. On the other hand, because the coronavirus disease 2019 (COVID-19) causes respiratory problems and...

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Autores principales: Sadeghi Dousari, Amin, Karimian Amroabadi, Marzieh, Soofi Neyestani, Zahra, Taati Moghadam, Majid, Satarzadeh, Naghmeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465882/
https://www.ncbi.nlm.nih.gov/pubmed/37654998
http://dx.doi.org/10.22038/AJP.2022.21607
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author Sadeghi Dousari, Amin
Karimian Amroabadi, Marzieh
Soofi Neyestani, Zahra
Taati Moghadam, Majid
Satarzadeh, Naghmeh
author_facet Sadeghi Dousari, Amin
Karimian Amroabadi, Marzieh
Soofi Neyestani, Zahra
Taati Moghadam, Majid
Satarzadeh, Naghmeh
author_sort Sadeghi Dousari, Amin
collection PubMed
description OBJECTIVE: Ephedra herbs are the only extant genus in its family, Ephedraceae, and order, Ephedrales. It has been prescribed in traditional medicine for improving headaches and respiratory infections. On the other hand, because the coronavirus disease 2019 (COVID-19) causes respiratory problems and COVID-19 pandemic is the most widespread outbreak that has affected humanity in the last century, the current review aims using literature search to investigate the effects of the Ephedra herbs compounds on COVID-19 to supply a reference for its clinical application in the inhibition and remedy of COVID-19. MATERIALS AND METHODS: This review was performed using articles published in various databases, including Web of Science, PubMed, Scopus, and Google Scholar, without a time limit. For this paper, the following keywords were used: "Ephedra", "coronavirus disease 2019", "COVID-19", "Severe acute respiratory syndrome coronavirus 2" or "SARS CoV 2". RESULTS: The results of this review show that the Ephedra herbs have effectiveness on COVID-19 and its compounds can bind to angiotensin-converting enzyme 2 (ACE2) with a high affinity and act as a blocker and prevent the binding of the virus. CONCLUSION: Some plants used in traditional medicine, including the Ephedra herbs, with their active compounds, can be considered a candidate with high potential for the control and prevention of COVID-19.
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spelling pubmed-104658822023-08-31 The use of Ephedra herbs in the treatment of COVID-19 Sadeghi Dousari, Amin Karimian Amroabadi, Marzieh Soofi Neyestani, Zahra Taati Moghadam, Majid Satarzadeh, Naghmeh Avicenna J Phytomed Review Article OBJECTIVE: Ephedra herbs are the only extant genus in its family, Ephedraceae, and order, Ephedrales. It has been prescribed in traditional medicine for improving headaches and respiratory infections. On the other hand, because the coronavirus disease 2019 (COVID-19) causes respiratory problems and COVID-19 pandemic is the most widespread outbreak that has affected humanity in the last century, the current review aims using literature search to investigate the effects of the Ephedra herbs compounds on COVID-19 to supply a reference for its clinical application in the inhibition and remedy of COVID-19. MATERIALS AND METHODS: This review was performed using articles published in various databases, including Web of Science, PubMed, Scopus, and Google Scholar, without a time limit. For this paper, the following keywords were used: "Ephedra", "coronavirus disease 2019", "COVID-19", "Severe acute respiratory syndrome coronavirus 2" or "SARS CoV 2". RESULTS: The results of this review show that the Ephedra herbs have effectiveness on COVID-19 and its compounds can bind to angiotensin-converting enzyme 2 (ACE2) with a high affinity and act as a blocker and prevent the binding of the virus. CONCLUSION: Some plants used in traditional medicine, including the Ephedra herbs, with their active compounds, can be considered a candidate with high potential for the control and prevention of COVID-19. Mashhad University of Medical Sciences 2023 /pmc/articles/PMC10465882/ /pubmed/37654998 http://dx.doi.org/10.22038/AJP.2022.21607 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sadeghi Dousari, Amin
Karimian Amroabadi, Marzieh
Soofi Neyestani, Zahra
Taati Moghadam, Majid
Satarzadeh, Naghmeh
The use of Ephedra herbs in the treatment of COVID-19
title The use of Ephedra herbs in the treatment of COVID-19
title_full The use of Ephedra herbs in the treatment of COVID-19
title_fullStr The use of Ephedra herbs in the treatment of COVID-19
title_full_unstemmed The use of Ephedra herbs in the treatment of COVID-19
title_short The use of Ephedra herbs in the treatment of COVID-19
title_sort use of ephedra herbs in the treatment of covid-19
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465882/
https://www.ncbi.nlm.nih.gov/pubmed/37654998
http://dx.doi.org/10.22038/AJP.2022.21607
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