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Magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: State of the art

BACKGROUND: Magnetic resonance imaging (MRI) is the dominant 3D imaging modality to quantify muscle properties in skeletal muscle disorders, in inherited and acquired muscle diseases, and in sarcopenia, in cachexia and frailty. METHODS: This review covers T1 weighted and Dixon sequences, introduces...

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Autores principales: Engelke, Klaus, Chaudry, Oliver, Gast, Lena, Eldib, Mootaz AB., Wang, Ling, Laredo, Jean-Denis, Schett, Georg, Nagel, Armin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465967/
https://www.ncbi.nlm.nih.gov/pubmed/37654433
http://dx.doi.org/10.1016/j.jot.2023.07.005
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author Engelke, Klaus
Chaudry, Oliver
Gast, Lena
Eldib, Mootaz AB.
Wang, Ling
Laredo, Jean-Denis
Schett, Georg
Nagel, Armin M.
author_facet Engelke, Klaus
Chaudry, Oliver
Gast, Lena
Eldib, Mootaz AB.
Wang, Ling
Laredo, Jean-Denis
Schett, Georg
Nagel, Armin M.
author_sort Engelke, Klaus
collection PubMed
description BACKGROUND: Magnetic resonance imaging (MRI) is the dominant 3D imaging modality to quantify muscle properties in skeletal muscle disorders, in inherited and acquired muscle diseases, and in sarcopenia, in cachexia and frailty. METHODS: This review covers T1 weighted and Dixon sequences, introduces T2 mapping, diffusion tensor imaging (DTI) and non-proton MRI. Technical concepts, strengths, limitations and translational aspects of these techniques are discussed in detail. Examples of clinical applications are outlined. For comparison (31)P-and (13)C-MR Spectroscopy are also addressed. RESULTS: MRI technology provides a rich toolset to assess muscle deterioration. In addition to classical measures such as muscle atrophy using T1 weighted imaging and fat infiltration using Dixon sequences, parameters characterizing inflammation from T2 maps, tissue sodium using non-proton MRI techniques or concentration or fiber architecture using diffusion tensor imaging may be useful for an even earlier diagnosis of the impairment of muscle quality. CONCLUSION: Quantitative MRI provides new options for muscle research and clinical applications. Current limitations that also impair its more widespread use in clinical trials are lack of standardization, ambiguity of image segmentation and analysis approaches, a multitude of outcome parameters without a clear strategy which ones to use and the lack of normal data.
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spelling pubmed-104659672023-08-31 Magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: State of the art Engelke, Klaus Chaudry, Oliver Gast, Lena Eldib, Mootaz AB. Wang, Ling Laredo, Jean-Denis Schett, Georg Nagel, Armin M. J Orthop Translat Review Article BACKGROUND: Magnetic resonance imaging (MRI) is the dominant 3D imaging modality to quantify muscle properties in skeletal muscle disorders, in inherited and acquired muscle diseases, and in sarcopenia, in cachexia and frailty. METHODS: This review covers T1 weighted and Dixon sequences, introduces T2 mapping, diffusion tensor imaging (DTI) and non-proton MRI. Technical concepts, strengths, limitations and translational aspects of these techniques are discussed in detail. Examples of clinical applications are outlined. For comparison (31)P-and (13)C-MR Spectroscopy are also addressed. RESULTS: MRI technology provides a rich toolset to assess muscle deterioration. In addition to classical measures such as muscle atrophy using T1 weighted imaging and fat infiltration using Dixon sequences, parameters characterizing inflammation from T2 maps, tissue sodium using non-proton MRI techniques or concentration or fiber architecture using diffusion tensor imaging may be useful for an even earlier diagnosis of the impairment of muscle quality. CONCLUSION: Quantitative MRI provides new options for muscle research and clinical applications. Current limitations that also impair its more widespread use in clinical trials are lack of standardization, ambiguity of image segmentation and analysis approaches, a multitude of outcome parameters without a clear strategy which ones to use and the lack of normal data. Chinese Speaking Orthopaedic Society 2023-08-19 /pmc/articles/PMC10465967/ /pubmed/37654433 http://dx.doi.org/10.1016/j.jot.2023.07.005 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Engelke, Klaus
Chaudry, Oliver
Gast, Lena
Eldib, Mootaz AB.
Wang, Ling
Laredo, Jean-Denis
Schett, Georg
Nagel, Armin M.
Magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: State of the art
title Magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: State of the art
title_full Magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: State of the art
title_fullStr Magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: State of the art
title_full_unstemmed Magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: State of the art
title_short Magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: State of the art
title_sort magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: state of the art
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465967/
https://www.ncbi.nlm.nih.gov/pubmed/37654433
http://dx.doi.org/10.1016/j.jot.2023.07.005
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