Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy

Radiotherapy is widely used in the management of advanced colorectal cancer (CRC). However, the clinical efficacy is limited by the safe irradiated dose. Sensitizing tumor cells to radiotherapy via interrupting DNA repair is a promising approach to conquering the limitation. The BRCA1–BARD1 complex...

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Detalles Bibliográficos
Autores principales: Yue, Xin, Liu, Tingyu, Wang, Xuecen, Wu, Weijian, Wen, Gesi, Yi, Yang, Wu, Jiaxin, Wang, Ziyang, Zhan, Weixiang, Wu, Ruirui, Meng, Yuan, Cao, Zhirui, Le, Liyuan, Qiu, Wenyan, Zhang, Xiaoyue, Li, Zhenyu, Chen, Yong, Wan, Guohui, Bu, Xianzhang, Peng, Zhenwei, Liu, Ran-yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466008/
https://www.ncbi.nlm.nih.gov/pubmed/37655321
http://dx.doi.org/10.1016/j.apsb.2023.05.017

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