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A nomogram-based optimized Radscore for preoperative prediction of lymph node metastasis in patients with cervical cancer after neoadjuvant chemotherapy

PURPOSE: To construct a superior single-sequence radiomics signature to assess lymphatic metastasis in patients with cervical cancer after neoadjuvant chemotherapy (NACT). METHODS: The first half of the study was retrospectively conducted in our hospital between October 2012 and December 2021. Based...

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Autores principales: Ai, Conghui, Zhang, Lan, Ding, Wei, Zhong, Suixing, Li, Zhenhui, Li, Miaomiao, Zhang, Huimei, Zhang, Lei, Hu, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466037/
https://www.ncbi.nlm.nih.gov/pubmed/37655103
http://dx.doi.org/10.3389/fonc.2023.1117339
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author Ai, Conghui
Zhang, Lan
Ding, Wei
Zhong, Suixing
Li, Zhenhui
Li, Miaomiao
Zhang, Huimei
Zhang, Lan
Zhang, Lei
Hu, Hongyan
author_facet Ai, Conghui
Zhang, Lan
Ding, Wei
Zhong, Suixing
Li, Zhenhui
Li, Miaomiao
Zhang, Huimei
Zhang, Lan
Zhang, Lei
Hu, Hongyan
author_sort Ai, Conghui
collection PubMed
description PURPOSE: To construct a superior single-sequence radiomics signature to assess lymphatic metastasis in patients with cervical cancer after neoadjuvant chemotherapy (NACT). METHODS: The first half of the study was retrospectively conducted in our hospital between October 2012 and December 2021. Based on the history of NACT before surgery, all pathologies were divided into the NACT and surgery groups. The incidence rate of lymphatic metastasis in the two groups was determined based on the results of pathological examination following lymphadenectomy. Patients from the primary and secondary centers who received NACT were enrolled for radiomics analysis in the second half of the study. The patient cohorts from the primary center were randomly divided into training and test cohorts at a ratio of 7:3. All patients underwent magnetic resonance imaging after NACT. Segmentation was performed on T1-weighted imaging (T1WI), T2-weighted imaging, contrast-enhanced T1WI (CET1WI), and diffusion-weighted imaging. RESULTS: The rate of lymphatic metastasis in the NACT group (33.2%) was significantly lower than that in the surgery group (58.7%, P=0.007). The area under the receiver operating characteristic curve values of Radscore_CET1WI for predicting lymph node metastasis and non-lymphatic metastasis were 0.800 and 0.797 in the training and test cohorts, respectively, exhibiting superior diagnostic performance. After combining the clinical variables, the tumor diameter on magnetic resonance imaging was incorporated into the Rad_clin model constructed using Radscore_CET1WI. The Hosmer–Lemeshow test of the Rad_clin model revealed no significant differences in the goodness of fit in the training (P=0.594) or test cohort (P=0.748). CONCLUSIONS: The Radscore provided by CET1WI may achieve a higher diagnostic performance in predicting lymph node metastasis. Superior performance was observed with the Rad_clin model.
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spelling pubmed-104660372023-08-31 A nomogram-based optimized Radscore for preoperative prediction of lymph node metastasis in patients with cervical cancer after neoadjuvant chemotherapy Ai, Conghui Zhang, Lan Ding, Wei Zhong, Suixing Li, Zhenhui Li, Miaomiao Zhang, Huimei Zhang, Lan Zhang, Lei Hu, Hongyan Front Oncol Oncology PURPOSE: To construct a superior single-sequence radiomics signature to assess lymphatic metastasis in patients with cervical cancer after neoadjuvant chemotherapy (NACT). METHODS: The first half of the study was retrospectively conducted in our hospital between October 2012 and December 2021. Based on the history of NACT before surgery, all pathologies were divided into the NACT and surgery groups. The incidence rate of lymphatic metastasis in the two groups was determined based on the results of pathological examination following lymphadenectomy. Patients from the primary and secondary centers who received NACT were enrolled for radiomics analysis in the second half of the study. The patient cohorts from the primary center were randomly divided into training and test cohorts at a ratio of 7:3. All patients underwent magnetic resonance imaging after NACT. Segmentation was performed on T1-weighted imaging (T1WI), T2-weighted imaging, contrast-enhanced T1WI (CET1WI), and diffusion-weighted imaging. RESULTS: The rate of lymphatic metastasis in the NACT group (33.2%) was significantly lower than that in the surgery group (58.7%, P=0.007). The area under the receiver operating characteristic curve values of Radscore_CET1WI for predicting lymph node metastasis and non-lymphatic metastasis were 0.800 and 0.797 in the training and test cohorts, respectively, exhibiting superior diagnostic performance. After combining the clinical variables, the tumor diameter on magnetic resonance imaging was incorporated into the Rad_clin model constructed using Radscore_CET1WI. The Hosmer–Lemeshow test of the Rad_clin model revealed no significant differences in the goodness of fit in the training (P=0.594) or test cohort (P=0.748). CONCLUSIONS: The Radscore provided by CET1WI may achieve a higher diagnostic performance in predicting lymph node metastasis. Superior performance was observed with the Rad_clin model. Frontiers Media S.A. 2023-08-15 /pmc/articles/PMC10466037/ /pubmed/37655103 http://dx.doi.org/10.3389/fonc.2023.1117339 Text en Copyright © 2023 Ai, Zhang, Ding, Zhong, Li, Li, Zhang, Zhang, Zhang and Hu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ai, Conghui
Zhang, Lan
Ding, Wei
Zhong, Suixing
Li, Zhenhui
Li, Miaomiao
Zhang, Huimei
Zhang, Lan
Zhang, Lei
Hu, Hongyan
A nomogram-based optimized Radscore for preoperative prediction of lymph node metastasis in patients with cervical cancer after neoadjuvant chemotherapy
title A nomogram-based optimized Radscore for preoperative prediction of lymph node metastasis in patients with cervical cancer after neoadjuvant chemotherapy
title_full A nomogram-based optimized Radscore for preoperative prediction of lymph node metastasis in patients with cervical cancer after neoadjuvant chemotherapy
title_fullStr A nomogram-based optimized Radscore for preoperative prediction of lymph node metastasis in patients with cervical cancer after neoadjuvant chemotherapy
title_full_unstemmed A nomogram-based optimized Radscore for preoperative prediction of lymph node metastasis in patients with cervical cancer after neoadjuvant chemotherapy
title_short A nomogram-based optimized Radscore for preoperative prediction of lymph node metastasis in patients with cervical cancer after neoadjuvant chemotherapy
title_sort nomogram-based optimized radscore for preoperative prediction of lymph node metastasis in patients with cervical cancer after neoadjuvant chemotherapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466037/
https://www.ncbi.nlm.nih.gov/pubmed/37655103
http://dx.doi.org/10.3389/fonc.2023.1117339
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