Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer’s disease

We investigated the inhibitory activities of novel 9-phosphoryl-9,10-dihydroacridines and 9-phosphorylacridines against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carboxylesterase (CES). We also studied the abilities of the new compounds to interfere with the self-aggregation of...

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Detalles Bibliográficos
Autores principales: Makhaeva, Galina F., Kovaleva, Nadezhda V., Rudakova, Elena V., Boltneva, Natalia P., Lushchekina, Sofya V., Astakhova, Tatiana Yu, Timokhina, Elena N., Serebryakova, Olga G., Shchepochkin, Alexander V., Averkov, Maxim A., Utepova, Irina A., Demina, Nadezhda S., Radchenko, Eugene V., Palyulin, Vladimir A., Fisenko, Vladimir P., Bachurin, Sergey O., Chupakhin, Oleg N., Charushin, Valery N., Richardson, Rudy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466253/
https://www.ncbi.nlm.nih.gov/pubmed/37654616
http://dx.doi.org/10.3389/fphar.2023.1219980

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