Chemical Probe for Imaging of Polo-like Kinase 4 and Centrioles

[Image: see text] Polo-like kinase (Plk4) is a serine/threonine-protein kinase that is essential for biogenesis of the centriole organelle and is enriched at centrioles. Herein, we introduce Cen-TCO, a chemical probe based on the Plk4 inhibitor centrinone, to image Plk4 and centrioles in live or fix...

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Detalles Bibliográficos
Autores principales: Salim, Aleksandar, Werther, Philipp, Hatzopoulos, Georgios N., Reymond, Luc, Wombacher, Richard, Gönczy, Pierre, Johnsson, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466336/
https://www.ncbi.nlm.nih.gov/pubmed/37654580
http://dx.doi.org/10.1021/jacsau.3c00271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466336/
https://www.ncbi.nlm.nih.gov/pubmed/37654580
http://dx.doi.org/10.1021/jacsau.3c00271

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