New Opportunities of Electrochemistry for Monitoring, Modulating, and Mimicking the Brain Signals

[Image: see text] In vivo electrochemistry is a powerful key for unlocking the chemical consequences in neural networks of the brain. The past half-century has witnessed the technology revolutionization in this field along with innovations in electrochemical concepts, principles, methods, and devices. Present applications of electrochemical approaches have extended from measuring neurochemical concentrations to modulating and mimicking brain signals. In this Perspective, newly reported strategies for tackling long-standing challenges of in vivo electrochemical brain monitoring (i.e., basal level measurement, electroactivity dependence, in vivo stability, neuron compatibility, multiplexity, and implantable device fabrication) are highlighted. Moreover, recent progress on neuromodulation tools and neuromorphic devices in electrochemical frameworks is introduced. A glimpse of future opportunities for electrochemistry in brain research is offered at last.