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Comparison of the IHC Markers CD138 and CD43 in Oral Leukoplakia: An Original Research

BACKGROUND: In the clinical practice, one of the most common suspicious lesions that may be potentially malignant is oral leukoplakia. Globally, the rate at which it turns malignant varies. This study examines the levels of markers CD138 and 43 in oral leukoplakia. MATERIALS AND METHODS: Twenty arch...

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Autores principales: Akkaloori, Anitha, Saikia, Jayanta, Kuppusamy, Anitha, Rana, Komal, Dashatwar, Pallavi D., Behura, Shyam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466614/
https://www.ncbi.nlm.nih.gov/pubmed/37654342
http://dx.doi.org/10.4103/jpbs.jpbs_454_22
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author Akkaloori, Anitha
Saikia, Jayanta
Kuppusamy, Anitha
Rana, Komal
Dashatwar, Pallavi D.
Behura, Shyam S.
author_facet Akkaloori, Anitha
Saikia, Jayanta
Kuppusamy, Anitha
Rana, Komal
Dashatwar, Pallavi D.
Behura, Shyam S.
author_sort Akkaloori, Anitha
collection PubMed
description BACKGROUND: In the clinical practice, one of the most common suspicious lesions that may be potentially malignant is oral leukoplakia. Globally, the rate at which it turns malignant varies. This study examines the levels of markers CD138 and 43 in oral leukoplakia. MATERIALS AND METHODS: Twenty archival blocks of confirmed epithelial dysplasia were taken from the Department of Oral Pathology. These were processed for the identification of markers CD138 and 43 through Immuno Histo Chemistry (IHC). The blocks were divided equally for both the markers. RESULTS: There was a noticeable difference in staining intensity between dysplastic tissue and nondysplastic epithelium. However, CD138 expression was low or weak in dysplastic epithelium. CD43 expression was negative in all nonhematopoietic tissues. CONCLUSION: Genes that are cancer associated have been found to have incredibly different impacts in numerous tissues during the multistep process of oral carcinogenesis. In tissues undergoing dysplastic changes, CD138 expression was shown to be decreased, which could point out the malignant changes initiated in the epithelium of the oral tissues.
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spelling pubmed-104666142023-08-31 Comparison of the IHC Markers CD138 and CD43 in Oral Leukoplakia: An Original Research Akkaloori, Anitha Saikia, Jayanta Kuppusamy, Anitha Rana, Komal Dashatwar, Pallavi D. Behura, Shyam S. J Pharm Bioallied Sci Original Article BACKGROUND: In the clinical practice, one of the most common suspicious lesions that may be potentially malignant is oral leukoplakia. Globally, the rate at which it turns malignant varies. This study examines the levels of markers CD138 and 43 in oral leukoplakia. MATERIALS AND METHODS: Twenty archival blocks of confirmed epithelial dysplasia were taken from the Department of Oral Pathology. These were processed for the identification of markers CD138 and 43 through Immuno Histo Chemistry (IHC). The blocks were divided equally for both the markers. RESULTS: There was a noticeable difference in staining intensity between dysplastic tissue and nondysplastic epithelium. However, CD138 expression was low or weak in dysplastic epithelium. CD43 expression was negative in all nonhematopoietic tissues. CONCLUSION: Genes that are cancer associated have been found to have incredibly different impacts in numerous tissues during the multistep process of oral carcinogenesis. In tissues undergoing dysplastic changes, CD138 expression was shown to be decreased, which could point out the malignant changes initiated in the epithelium of the oral tissues. Wolters Kluwer - Medknow 2023-07 2023-07-05 /pmc/articles/PMC10466614/ /pubmed/37654342 http://dx.doi.org/10.4103/jpbs.jpbs_454_22 Text en Copyright: © 2023 Journal of Pharmacy and Bioallied Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Akkaloori, Anitha
Saikia, Jayanta
Kuppusamy, Anitha
Rana, Komal
Dashatwar, Pallavi D.
Behura, Shyam S.
Comparison of the IHC Markers CD138 and CD43 in Oral Leukoplakia: An Original Research
title Comparison of the IHC Markers CD138 and CD43 in Oral Leukoplakia: An Original Research
title_full Comparison of the IHC Markers CD138 and CD43 in Oral Leukoplakia: An Original Research
title_fullStr Comparison of the IHC Markers CD138 and CD43 in Oral Leukoplakia: An Original Research
title_full_unstemmed Comparison of the IHC Markers CD138 and CD43 in Oral Leukoplakia: An Original Research
title_short Comparison of the IHC Markers CD138 and CD43 in Oral Leukoplakia: An Original Research
title_sort comparison of the ihc markers cd138 and cd43 in oral leukoplakia: an original research
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466614/
https://www.ncbi.nlm.nih.gov/pubmed/37654342
http://dx.doi.org/10.4103/jpbs.jpbs_454_22
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